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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival. Lysophosphatidic acid (LPA) is a bioactive lipid mediator that promotes various cellular processes, including cell survival, proliferation, metastasis, and invasion. Signal transducer and activator of transcription (STATs) are transcription factors that mediate gene expression. Among the seven types of STATs in mammals, STAT3 is involved in invasion and metastasis of numerous tumors. However, little is known about the role of STAT3 in oral tumor invasion. In the present study, we hypothesized that STAT3 mediates LPA-induced oral cancer invasion. Methods: Immunoblotting was performed to analyze LPA-induced STAT3 activation. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was performed to assess the survival rates of YD-10B cells. STAT3 levels in LPA-treated oral tumor cells were evaluated by performing in vitro invasion assay. Results: To the best of our knowledge, this is the first study to demonstrate that LPA enhances STAT3 phosphorylation in oral cancer. In addition, treatment with WP1066, a selective inhibitor of STAT3, at a concentration that does not cause severe reduction in cell viability, significantly attenuated LPA-induced YD-10B cancer cell invasion. Conclusion: The results suggested that LPA induces oral tumor cells with greater invasive potential via STAT3 activation. Our findings provided important insights into the mechanisms underlying mouth neoplasms.
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참고문헌 (21)
참고문헌 신청
Changqing Xie / 2019 / The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers / Molecular Cancer 18(1)
Everett E. Vokes / 1993 / Head and Neck Cancer / New England Journal of Medicine 328(3):184~194
Freddie Bray / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA: A Cancer Journal for Clinicians 68(6):394~424
K Dhanuthai / 2017 / Oral cancer: A multicenter study / Medicina Oral Patología Oral y Cirugia Bucal :0~0
Malay Kumar / 2016 / Oral cancer: Etiology and risk factors: A review / Journal of Cancer Research and Therapeutics 12(2):458
Everett E. Vokes / 1993 / Head and Neck Cancer / New England Journal of Medicine 328(3):184~194
Freddie Bray / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA: A Cancer Journal for Clinicians 68(6):394~424
K Dhanuthai / 2017 / Oral cancer: A multicenter study / Medicina Oral Patología Oral y Cirugia Bucal :0~0
Malay Kumar / 2016 / Oral cancer: Etiology and risk factors: A review / Journal of Cancer Research and Therapeutics 12(2):458
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Blockade of STAT3 in T Cells Inhibits Germinal Center Reactions against Intranasal Allergens
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Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis
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Cadmium-induced oxidative stress regulation of mitochondria STAT3
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