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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Relative to its incidence, oral cancer has serious negative social effects. The exact causes of oral cancer have not been clarified, but many studieshave implicated smoking and drinking. However, the fundamental mechanism of oral cancer causation has yet to be elucidated. Lysophosphatidicacid (LPA) augments epithelial mesenchymal transition (EMT) and development of various cancer cells. However, a detailed mechanisticexplanation for LPA-induced EMT and the effects of EMT-promoting conditions on oral squamous cell carcinoma development remain elusive. Inthe present study, a quantitative reverse transcription polymerase chain reaction was used to analyze TWIST1, Slug, E-cadherin, andglyceraldehyde-3-phosphate dehydrogenase (GAPDH) transcript expression. Immunoblotting was used to analyze TWIST1, Slug, E-cadherin, andGAPDH protein expression. siRNAs were used to silence TWIST1 and Slug transcript expression. A matrigel-coated in vitro invasion insert was usedto analyze oral cancer cell invasion. The results of the present study show that the expression levels of TWIST1 and Slug, which are EMT factors,were increased by LPA treatment in YD-10B oral squamous cell carcinoma. Conversely, E-cadherin expression was significantly reduced. Inaddition, transfection of the cells with TWIST1 and Slug siRNA strongly inhibited LPA-induced oral cancer cell invasion. The present study showsthat TWIST1 and Slug mediate LPA-induced oral cancer cell EMT and invasiveness. The present study confirmed the mechanism by which LPApromotes oral cancer cell development, with TWIST1 and Slug providing novel biomarkers and promising therapeutic targets for oral cancer celldevelopment.
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참고문헌 (25)
참고문헌 신청
Anliker B / 2004 / Cell surface receptors in lysophospholipid signaling / Semin Cell Dev Biol 15 : 457 ~ 465
Bathena SP / 2011 / Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS / J Pharm Biomed Anal 56 : 402
Beavon IR / 2000 / The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation / Eur J Cancer 36 : 1607 ~ 1620
Bian D / 2004 / Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway / Cancer Res 64 : 4209 ~ 4217
Bian D / 2006 / The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration / Oncogene 25 : 2234 ~ 2244
Bathena SP / 2011 / Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS / J Pharm Biomed Anal 56 : 402
Beavon IR / 2000 / The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation / Eur J Cancer 36 : 1607 ~ 1620
Bian D / 2004 / Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway / Cancer Res 64 : 4209 ~ 4217
Bian D / 2006 / The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration / Oncogene 25 : 2234 ~ 2244
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