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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 109 - 112 (4page)
이용수
초록· 키워드
오류제보하기
Nowadays antibiotic resistance is a worldwide serious problem that mainly affects public health. Omadacycline is a unique antibiotic which has two available dosage forms such as intravenous (IV) and oral that development for community-acquired bacterial infectious disease treatment. It is a modified form of older tetracycline at C-9 aminomethyl substituent of 6-member core ring of tetracycline. Modification form shows its activity against efflux pump and ribosomal protein protection mechanism of tetracycline resistance. Generally, omadacycline is effective against methicillin-resistant S. aureus (MRSA), Streptococcus pneumoniae, vancomycinresistant Enterococcus (VRE), Legionella and Chlamydia spp. Efficacy, safety and tolerability profile of omadacycline those compares with recent antibiotics shows that omadacycline is less resistant than others. One derivative from tetracycline derivatives is 9-neopentylaminomethylminocycline called omadacycline was discovered and ongoing phase III clinical experiments as a therapy for acute bacterial skin and skin structure infections (ABSSSI) as well as community-acquired bacterial pneumonia (CABP). Omadacycline seems to be a strong drug candidate for future promising new antibacterial agent that is effective against ABSSSI and CABP.
목차
INTRODUCTION
DISCOVERY AND STRUCTURE ACTIVITY RELATIONSHIP OF OMADACYCLINE
MECHANISM OF ACTION OF OMADACYCLINE
WAY TO OVERCOME THE TETRACYCLINE RESISTANCE
IN VITRO AND IN VIVO STUDIES OF OMADACYCLINE
TRANSPORTER EFFECTS OF OMADACYCLINE
CLINICAL PROFILE AND EFFICACY OF OMADACYCLINE
CLOSING REMARKS
REFERENCES
참고문헌 (11)
참고문헌 신청
[학술지(정기간행물)] - Tanaka SK / 2016 / Discovery, pharmacology and clinical profile of omadacycline, a novel aminomethylcycline antibiotic / Bioorg Med Chem 24 : 6409 ~ 6419
[학술지(정기간행물)] - Honeyman L / 2015 / Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline / Antimicrob Agents Chemother 59 : 7044 ~ 7053
[학술지(정기간행물)] - Chopra I / 2001 / Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance / Microbiol Mol Biol Rev 65 : 232 ~ 260
[학술지(정기간행물)] - Draper MP / 2014 / Mechanism of action of the novel aminomethylcycline antibiotic omadacycline / Antimicrob Agents Chemother 58 : 1279 ~ 1283
[학술지(정기간행물)] - Macone AB / 2014 / In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline / Antimicrob Agents Chemother 58 : 1127 ~ 1135
[학술지(정기간행물)] - Honeyman L / 2015 / Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline / Antimicrob Agents Chemother 59 : 7044 ~ 7053
[학술지(정기간행물)] - Chopra I / 2001 / Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance / Microbiol Mol Biol Rev 65 : 232 ~ 260
[학술지(정기간행물)] - Draper MP / 2014 / Mechanism of action of the novel aminomethylcycline antibiotic omadacycline / Antimicrob Agents Chemother 58 : 1279 ~ 1283
[학술지(정기간행물)] - Macone AB / 2014 / In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline / Antimicrob Agents Chemother 58 : 1127 ~ 1135
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UCI(KEPA) : I410-ECN-0101-2018-475-003564189