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초록· 키워드
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Phase transition is not unique to solid state systems or homogeneous molecular systems but it is also observed in highly heterogeneous biological systems. Phase transition and phase separation in cells are recently being found to be central to many biological functions by temporarily and locally controlling the storage and exchange of certain proteins and RNAs. There are also clues suggesting them to be playing pivotal roles in the spatial organization of chromosomes into topological domains and its time-dependent control. Here we introduce early efforts to explain at the molecular level how the spatiotemporal organization of chromosomes are programmed and modulated by the sequence and chemical modifications of the DNA. Continuing works may provide a physical framework to understand the molecular level control of chromosome structure and dynamics that determine the epigenetic state and the fate of the cells.
목차
세포에서의 상전이와 상분리
염색체의 도메인 구조와 상분리
DNA-DNA 상호작용의 측정
열린 결말
References
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UCI(KEPA) : I410-ECN-0101-2019-420-000021806