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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 512 - 522 (11page)
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초록· 키워드
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Chromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin structure have uncovered organizational principles of the 3D genome and its various biological implications. Very recently, it has been reported that large-scale genomic variations may disrupt higher-order chromatin organization and as a consequence, greatly contribute to disease-specific gene regulation for a range of human diseases. Here, we review recent developments in studying the effect of structural variation in gene regulation, and the detection and the interpretation of structural variations in the context of 3D chromatin structure.
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참고문헌 (67)
참고문헌 신청
Alkan, C. / 2011 / Genome structural variation discovery and genotyping / Nat. Rev. Genet 12:363~376
Baca, S. C. / 2013 / Punctuated evolution of prostate cancer genomes / Cell 153:666~677
Burton, J. N. / 2013 / Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions / Nat. Biotechnol 31:1119~1125
Campbell, P. J. / 2008 / Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing / Nat. Genet 40:722~729
Chaisson, M. J. P. / 2019 / Multiplatform discovery of haplotype-resolved structural variation in human genomes / Nat. Commun 10:1784
Baca, S. C. / 2013 / Punctuated evolution of prostate cancer genomes / Cell 153:666~677
Burton, J. N. / 2013 / Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions / Nat. Biotechnol 31:1119~1125
Campbell, P. J. / 2008 / Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing / Nat. Genet 40:722~729
Chaisson, M. J. P. / 2019 / Multiplatform discovery of haplotype-resolved structural variation in human genomes / Nat. Commun 10:1784
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