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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 281 - 287 (7page)
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초록· 키워드
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Recent advancements in sequencing and imaging technologies are providing new perspectives in solving the mystery of three-dimensional folding of genome in a nucleus. Chromosome conformation capture sequencing has discovered new chromatin structures such as topologically associated domains and loops in hundreds of kilobases. Super-resolution fluorescence microscopy with nanometer resolutions, in particular multiplexed approaches with sequence-specificity, has visualized chromatin structures from the rough folds of whole chromosomes to the fine loops of cis-regulatory elements in intact individual nuclei. Here, recent advancements in genome visualization tools with highly multiplexed labeling and reading are introduced. These imaging technologies have found ensemble behavior consistent to sequencing results, while unveiling single-cell variations. But, they also generated contradictory results on the roles of architectural proteins (like cohesion and CTCF) and enhancer-promoter interactions. Live-cell labeling methods for imaging specific genomic loci, especially the CRISPR/dCas9 system, are reviewed in order to give perspectives in the emergence of tools for visualizing genome structural dynamics.
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참고문헌 (40)
참고문헌 신청
Beliveau BJ / 2017 / Super resolut microsc methods protocols / Springer :231~252
Bintu B / 2018 / Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells / Science 362:419~419
Boettiger AN / 2016 / Superresolution imaging reveals distinct chromatin folding for diferent epigenetic states / Nature 529:418~418
Chen BH / 2013 / Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system / Cell 155:1479~1491
Chen KH / 2015 / Spatially resolved, highly multiplexed RNA profling in single cells / Science 348:aaa6090
Bintu B / 2018 / Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells / Science 362:419~419
Boettiger AN / 2016 / Superresolution imaging reveals distinct chromatin folding for diferent epigenetic states / Nature 529:418~418
Chen BH / 2013 / Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system / Cell 155:1479~1491
Chen KH / 2015 / Spatially resolved, highly multiplexed RNA profling in single cells / Science 348:aaa6090
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