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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 365 - 371 (7page)
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In this study, antioxidant and anti-neuroinflammatory of ethanol extracts from walnuts`s (Juglans regia L.) shell were investigated in vitro. Radical-scavenging activities of the walnuts"s shell ethanol extracts (WSE) were examined by using ABTS radicals and α,α-diphenyl-β-picrylhydrazyl (DPPH) radicals assay. In the ABTS and DPPH radical scavenging activity, RC<SUB>50</SUB> of WSE were measured as 15.74 and 40.13 μg/mL, respectively. Also, to evaluate the anti-neuroinflammatory effects of WSE in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. The production of proinflammatory cytokines NO were examined by LPS in BV-2 cell. BV-2 cells activated with LPS were treated with various doses (10, 25, 50, 100 μg/mL) of WSE. Supernatants were analyzed for the production of NO using Griess reagent. WSE up to 10 μg/mL still required to inhibit NO induced by LPS. These results showed that walnuts`s (Juglans regia L.) shell can be used as an easily accessible source of natural anti-neuroinflammatory and natural antioxidants.
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UCI(KEPA) : I410-ECN-0101-2019-510-000302792