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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 411 - 415 (5page)
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초록· 키워드
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To evaluate the protective effects of Plantago Major extract (PME) in stimulated BV-2 microglial cells and its anti-oxidant properties, cell viability assessment was performed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Lipopolysaccharide (LPS) was used to activate BV-2 microglia. Nitric oxide (NO) levels were measured using Griess assay. Tumor necrosis factor-alpha (TNF-α) production was evaluated by enzyme-linked immunosorbent assay (ELISA). Antioxidant properties were evaluated by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. LPS-activated excessive release of NO in BV-2 cells was significantly inhibited by PME (P < 0.001 at 100 μg/mL). PME also scavenged DPPH radicals in a dose-dependent manner (P < 0.05 at 10 μg/mL and P < 0.001 at 20~200 μg/mL). These results indicate that PME attenuated neuroinflammatory responses in LPS-activated BV-2 microglia by inhibiting excessive production of pro-inflammatory mediators such as NO and TNF-α. The anti-neuroinflammatory potential of PME may be related to its strong antioxidant properties.
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참고문헌 (18)
참고문헌 신청
Bruno R, Dugan C, Smyth J, DiNatale D, Koo S. Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury. American Society for Nutrition. 2008. 21: 323-331.
Beara IN, Lesjak MM, Jovin ED, Balog KJ, Anackov GT, Orcic DZ. Plantain (Plantago L.) species as novel sources of flavonoid antioxidants. Journal of Agricultural and Food Chemistry. 2009. 57: 9268-9273.
Chiang LC, Chiang W, Chang MY, Lin CC. In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago Major and Plantago asiatica. The American Journal of Chinese Medicine. 2003. 31: 225-234.
Finkel T, Holbrook NJ. Oxidants. oxidative stress and the biology of ageing. Nature. 2000. 408: 239-247.
Frankola KA, Greig NH, Luo W, Tweedie D. Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS & Neurological Disorders Drug Targets. 2011. 10: 391-403.
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UCI(KEPA) : I410-ECN-0101-2018-510-001723333