지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Hepatitis refers to inflammation of hepatocytes and liver tissue, and is mainly caused by viruses, alcohol, and drugs. Forsythiae Fructus has traditionally been used as a diuretic, anti-inflammatory and antip/yretic. Research on rengyolone, a bioactive substance extracted from Forsythiae Fructus, is rarely found in Korea and abroad. First, an acute animal toxicity test for rengyolone was conducted for the animal experiment. 4 week-old SD rats were injected intraperitoneally with acetaminophen for 2 weeks to induce chronic liver inflammation. Rengyolone was orally administered into two groups during 4 weeks: pre-inflammatory group and post-inflammatory group. Oral doses were also divided into 1 mg/kg and 5 mg/kg. Liver function tests (ALT, AST, ALP), western blot analysis of liver tissue, and level of inflammatory cytokine were performed to evaluate the improvement of hepatitis. Experimental results showed that rengyolone inhibited the development of acute inflammation and thus could reduce hepatitis symptoms.
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고찰
REFERENCES
참고문헌 (15)
참고문헌 신청
Ahn BM / 2006 / Acetaminophen-Induced Acute Liver Failure / J Korean Med Assoc 49:846~853
Brown GC / 2008 / Mechanisms of inflammatory neuro degeneration: iNOS and NADPH oxidase / Biochem Soc Trans 35:1119~1121
Debnath T / 2013 / Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease / Molecules 19(18):7253~7270
Gressner OA / 2007 / Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests / Clin Chim Acta 381:107~113
Kanzler S / 2007 / Liver function test to predict hepatic failure after liver resection--expensive and without clinical relevance / Zentralbl Chir 132:267~273
Brown GC / 2008 / Mechanisms of inflammatory neuro degeneration: iNOS and NADPH oxidase / Biochem Soc Trans 35:1119~1121
Debnath T / 2013 / Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease / Molecules 19(18):7253~7270
Gressner OA / 2007 / Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests / Clin Chim Acta 381:107~113
Kanzler S / 2007 / Liver function test to predict hepatic failure after liver resection--expensive and without clinical relevance / Zentralbl Chir 132:267~273
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UCI(KEPA) : I410-ECN-0101-2019-510-000546432