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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.8
- 수록면
- 259 - 269 (11page)
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This study was performed to determined the antioxdant activities, anticancer and immuno-activities of anthocyanin fraction from Rubus coreanus Miquel fruits (Bokbunja). Anthocyanin fraction extracted from Bokbunja revealed the presence of three anthocyanin components, which were tentatively identified as cyanidin 3-O-sambubioside, cyanidin 3-O-xylosylrutinoside and cyanidin 3-O-rutinoside using RP-HPLC/DAD/MS. The anthocyanin fraction from Bokbunja always showed reducing power and high and high scavenging activities against DPPH, hydroxy radical (OH) and superoxide anion radical (O<sub>2</sub>-) similar to general synthetic antioxidant and polyphenol compounds from plant origin. Anthocyanin fraction from Bokbunja showed high inhibition on proliferation of LNCaP and A549 cells and did not inhibit the proliferation of other cancer cells. Immuno-activities of Anthocyanin fraction from Bokbunja were investigated, it showed high promotion of human B and T cells growth about 50% and secretion of IL-6 and TNF-α by treatment after 6 days. Over all, the result of the study suggest that anthocyanin fraction from Bokbunja displays antioxidant activity comparable to that general synthetic antioxidant, also, anthocyanin fraction from Bokbunja are expected to be good candidate for development into source of anticaner and immuno-activator agent in food industyr.
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참고문헌 (46)
참고문헌 신청
Acquaviva R / 2003 / Cyanidin and cyanidin 3-O-beta-D-glucoside as DNA cleavage protectors and antioxidants / Cell Biology and Toxicology 19:243~252
Ames BN / 1993 / Oxidants, antioxidants, and the degenerative diseases of aging / Proceedings of the National Academy of Sciences of the United states of America 90:7915~7922
Baeuerle PA / 1997 / NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules / Advances in Immunology 65:111~137
Byamukama R / 2005 / Anthocyanins from fruits of Rubus pinnatus and Rubus rigidus / Journal of Food Composition and Analysis 18:599~605
Calfee-Mason KG / 2002 / Vitamin E inhibits hepatic NF-κB activation in rats administered the hepatic tumor promoter, phenobarbital / Journal of Nutrition 132:3178~3185
Ames BN / 1993 / Oxidants, antioxidants, and the degenerative diseases of aging / Proceedings of the National Academy of Sciences of the United states of America 90:7915~7922
Baeuerle PA / 1997 / NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules / Advances in Immunology 65:111~137
Byamukama R / 2005 / Anthocyanins from fruits of Rubus pinnatus and Rubus rigidus / Journal of Food Composition and Analysis 18:599~605
Calfee-Mason KG / 2002 / Vitamin E inhibits hepatic NF-κB activation in rats administered the hepatic tumor promoter, phenobarbital / Journal of Nutrition 132:3178~3185
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UCI(KEPA) : I410-ECN-0101-2019-480-000588928