지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 103 - 117 (15page)
이용수
초록· 키워드
오류제보하기
The mixture of 5-chloro-2-methylisothiazol-3(2H)-one (CMIT) and 2-methylisothiazol-3(2H)-one (MIT), CMIT/MIT, is a preservative in cosmetics. CMIT/MIT is a highly effective preservative; however, it is also a commonly known skin sensitizer. Therefore, in the present study, a risk assessment for safety management of CMIT/MIT was conducted on products containing 0.0015% of CMIT/MIT, which is the maximum MIT level allowed in current products. The no observed adverse effect level (NOAEL) for CMIT/MIT was 2.8 ㎎/㎏ bw/day obtained from a two-generation reproductive toxicity test, and the skin sensitization toxicity standard value for CMIT/MIT, or the no expected sensitization induction level (NESIL), was 1.25 ㎍/㎠/day in humans. According to a calculation of body exposure to cosmetics use, the systemic exposure dosage (SED) was calculated as 0.00423 ㎎/㎏ bw/day when leave-on and rinse-off products were considered. Additionally, the consumer exposure level (CEL) amounted to 0.77512 ㎍/㎠/day for all representative cosmetics and 0.00584 ㎍/㎠/day for rinse-off products only. As a result, the non-cancer margin of safety (MOS) was calculated as 633, and CMIT/MIT was determined to be safe when all representative cosmetics were evaluated. In addition, the skin sensitization acceptable exposure level (AEL)/CEL was calculated as 0.00538 for all representative cosmetics and 2.14225 for rinse-off products; thus, CMIT/MIT was considered a skin sensitizer when all representative cosmetics were evaluated. Current regulations indicate that CMIT/MIT can only be used at concentrations 0.0015% or less and is prohibited from use in other cosmetics products. According to the results of this risk assessment, the CMIT/MIT regulatory values currently used in cosmetics are evaluated as appropriate.
목차
Abstract
INTRODUCTION
COMMERCIAL USE
HAZARD IDENTIFICATION
HAZARD DETERMINATION
EXPOSURE ASSESSMENT
RISK CHARACTERIZATION
SUMMARY AND CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
Environmental Analysis Health and Toxicology
2020 .06
-
CMIT/MIT 함유 가습기 살균제 제품의 제조 및 판매기업 형사판결 1심 재판 판결문에 대한 과학적 고찰 (I) - 제품 위험성과 노출평가 측면에서
한국환경보건학회지
2021 .04
-
For quantitative analysis of MIT/CMIT in household chemical products Standard material development research
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
Standard material development research for quantitative analysis of MIT/CMIT in household chemical products
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
마우스의 기도 내 점적을 통한 가습기살균제 CMIT/MIT와 사망 간의 원인적 연관성에 관한 연구
한국환경보건학회지
2017 .08
-
CMIT/MIT-induced mitochondrial damage contributes to functional impairment of blood-brain barrier (BBB)
환경독성보건학회 심포지엄 및 학술대회
2023 .05
-
Chloromethylisothiazolinone (CMIT)과 Methylisothiazolinone (MIT)의 건강영향에 대한 고찰 - 가습기 살균제 폐 손상을 중심으로 -
한국환경보건학회지
2020 .01
-
임신마우스에 기도 점적투여를 통한 가습기살균제 CMIT/MIT의 사산에 대한 영향
한국환경보건학회지
2018 .01
-
CMIT/MIT 함유 가습기 살균제 제품의 제조 및 판매기업 형사판결 1심 재판 판결문에 대한 과학적 고찰 (II) - 동물실험, 폐 손상 판정기준, 개인 인과
한국환경보건학회지
2021 .06
-
The chemical mixture of CMIT and MIT induces mouse type II epithelial cell damage and inflammatory responses in vivo
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Review of Inhalation Health Risks Involving Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) Used as Disinfectants in Household Humidifiers
Journal of Korean Medical Science
2022 .04
-
Identification of Quantitative Adverse Outcome Pathway of CMIT/MIT in respiratory diseases based on transcriptomic profiling
환경독성보건학회 심포지엄 및 학술대회
2023 .05
-
Species and strain differences on toxic response to biocide, CMIT/MIT exposure in Daphnia sp . : Epigenetics and Proteomics analysis
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Mixture Toxicity of Methylisothiazolinone and Propylene Glycol at a Maximum Concentration for Personal Care Products
Toxicological Research
2018 .10
-
Transgenerational effects of CMIT/MIT in Daphnia magna : Multi-level approach
환경독성보건학회 심포지엄 및 학술대회
2018 .06
-
The critical window of exposure of biocide, CMIT/MIT in zebrafish Danio rerio : epigenetics, developmental and behavioral analysis
환경독성보건학회 심포지엄 및 학술대회
2018 .06
-
Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Physical analysis reveals distinct responses of human bronchial epithelial cells to PHMG and CMIT/MIT biocides
환경독성보건학회 심포지엄 및 학술대회
2020 .09
-
Comparison of the toxic effects of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) on the respiratory system in mice
환경독성보건학회 심포지엄 및 학술대회
2023 .11
-
4-weeks inhalation study for Chloromethylisothiazolinone and Methylisothiazolinone (CMIT/MIT) in C57BL/6 mice
환경독성보건학회 심포지엄 및 학술대회
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-513-000530619