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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 355 - 361 (7page)
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초록· 키워드
오류제보하기
Methylisothiazolinone (MIT) has been used in combination with methylchloroisothiazolinone (CMIT) for cosmetic products such as shampoo, body lotion, and skin care products. The mixture of CMIT/MIT has been found to cause allergic contact dermatitis and is thus no longer permitted for use as a preservative in leave-on cosmetics. However, MIT itself was approved as a stand-alone preservative at a maximum concentration of 100 ppm as the toxicity was derived from CMIT rather than MIT. However, in many countries, allergic skin irritation caused by MIT remains a social concern. In this study, skin irritation was assessed for the presence of MIT, propylene glycol, and their mixture using a 3D human skin model EpiDermTM. Although non-diluted MIT causes serious skin toxicity, skin irritation was not observed at a concentration of 100 ppm, the maximum permissible level for cosmetics and personal care products according to European regulations. Propylene glycol, the most widely used vehicle for MIT, did not cause skin irritation in the 3D skin model. The results are expected to provide information for regulatory policies and guidelines on the use of biocides in consumer products.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (3)
참고문헌 신청
김혜진 / 2016 / Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM / 한국독성학회지 32(4):311~316
박동욱 / 2016 / 가습기 살균제 피해자 호흡기로 흡입된 가습기 살균제 양 추정 - 호흡기 외부(external) 및 내부 노출(internal exposure) 추정 방법과 사례 - / 한국환경보건학회지 42(3):141~146
이미리 / 2017 / Alternatives to In Vivo Draize Rabbit Eye and Skin Irritation Tests with a Focus on 3D Reconstructed Human Cornea-Like Epithelium and Epidermis Models / 한국독성학회지 33(3):191~203
박동욱 / 2016 / 가습기 살균제 피해자 호흡기로 흡입된 가습기 살균제 양 추정 - 호흡기 외부(external) 및 내부 노출(internal exposure) 추정 방법과 사례 - / 한국환경보건학회지 42(3):141~146
이미리 / 2017 / Alternatives to In Vivo Draize Rabbit Eye and Skin Irritation Tests with a Focus on 3D Reconstructed Human Cornea-Like Epithelium and Epidermis Models / 한국독성학회지 33(3):191~203
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Mixture toxicity of methylisothiazolinone and propylene glycol on the skin irritation tested by human 3D skin model, EpiDerm™
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Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics
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Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM
Toxicological Research
2016 .10
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Chloromethylisothiazolinone (CMIT)과 Methylisothiazolinone (MIT)의 건강영향에 대한 고찰 - 가습기 살균제 폐 손상을 중심으로 -
한국환경보건학회지
2020 .01
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임신마우스에 기도 점적투여를 통한 가습기살균제 CMIT/MIT의 사산에 대한 영향
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Toxicity Assessment of NCS in Experimental Animals
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Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium
Environmental Analysis Health and Toxicology
2019 .06
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마우스의 기도 내 점적을 통한 가습기살균제 CMIT/MIT와 사망 간의 원인적 연관성에 관한 연구
한국환경보건학회지
2017 .08
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Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
Environmental Analysis Health and Toxicology
2020 .06
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4-weeks inhalation study for Chloromethylisothiazolinone and Methylisothiazolinone (CMIT/MIT) in C57BL/6 mice
환경독성보건학회 심포지엄 및 학술대회
2022 .10
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Skin Irritation Test of chemical mixtures using Reconstructed Human Skin Models, Epiderm™
환경독성보건학회 심포지엄 및 학술대회
2016 .06
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For quantitative analysis of MIT/CMIT in household chemical products Standard material development research
환경독성보건학회 심포지엄 및 학술대회
2021 .10
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A study on the mechanism of chloromethylisothiazolinone and methylisothiazolinone(CMIT/MIT)-induced lung injury using in vitro and in vivo systems
환경독성보건학회 심포지엄 및 학술대회
2022 .10
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Standard material development research for quantitative analysis of MIT/CMIT in household chemical products
환경독성보건학회 심포지엄 및 학술대회
2022 .05
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Effect of animal strain and exposure route on chloromethylisothiazolinone and methylisothiazolinone(CMIT/MIT)-induced lung injury
환경독성보건학회 심포지엄 및 학술대회
2022 .10
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Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium
환경독성보건학회 심포지엄 및 학술대회
2022 .05
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Comparison of the toxic effects of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) on the respiratory system in mice
환경독성보건학회 심포지엄 및 학술대회
2023 .11
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CMIT/MIT-induced mitochondrial damage contributes to functional impairment of blood-brain barrier (BBB)
환경독성보건학회 심포지엄 및 학술대회
2023 .05
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The chemical mixture of CMIT and MIT induces mouse type II epithelial cell damage and inflammatory responses in vivo
한국실험동물학회 학술발표대회 논문집
2018 .01
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Review of Inhalation Health Risks Involving Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) Used as Disinfectants in Household Humidifiers
Journal of Korean Medical Science
2022 .04
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UCI(KEPA) : I410-ECN-0101-2018-513-003589396