지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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This study manufactured hydrogel, which was contained NSAIDs(non-steroidal anti-inflammatory drugs)Ketorolac tromethamine and hydrolyzed products of gardeniae fructus extract, and experimented viscosity, surface tension, tensile strength and bio-adhesiveness by using hairless mouse. Thus, it was performed in expectation for being probably able to develop as effective auxiliary agent of periodontal disease after non-surgical or surgical periodontal treatment. As a result, the following conclusions were obtained. 1. Out of KGE and KGH gel materials, the content of ketorolac tromethamine was 1.02~0.97%. The content of geniposide was 0.34% in KGE gel A and C. However, it got lower to 0.11% in KGH gel B and D. The content of genipin wasn't shown in KGE gel A and C, but was shown with 0.13% in KGH gel B and D. 2. As for viscosity according to temperature in gel material, the gel, which used independently Carbopol 940 as gel inoculant, maintained the higher viscosity than the gel, which added Poloxamer 407.
The surface tension in each material showed 34.77~40.58 dyne/cm at 37. As for tensile strength in material, KGH gel B was shown the higher tensile strength in about 3.5 times compared to the control group. 3. As for bio-adhesiveness, the back-skin upper part(epidermis) and abdomen skin were shown to be 50.62 N in KGH gel B, thereby having indicated higher value in about 5 times compared to control group. The back-skin lower part(dermis) and abdomen skin were shown to be 35.93 N in KGH gel B, thereby having indicated higher value in about 3.5 times compared to control group.
목차
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참고문헌 (14)
참고문헌 신청
Akao T / 1994 / Enzymatic studies on the animal and intestinal bacterial methabolism of geniposide / Biol Pharm Bull 17 (12) : 1573 ~ 1576
Buckley MMT / 1990 / Ketorolac, A review of its pharmacodynamic and Pharmacokinetic properties and therapeutic potenital / Drug 39 (1) : 86 ~ 109
Chun MK / 2003 / Preparation of buccal patch composed of carbobol, poloxamer and hydroxypropyl methylcellulose / Arch Pharm Res 26 (11) : 973 ~ 978
Grandos-Soto V / 1995 / Evidence against the participation of μ-and -opioid receptors in the analgesic activity of ketorolac in rats / J Pharm Pharmacol 47 (6) : 514 ~ 517
Jeffcoat MK / 1995 / A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis / J Periodontol 66 (5) : 529
Buckley MMT / 1990 / Ketorolac, A review of its pharmacodynamic and Pharmacokinetic properties and therapeutic potenital / Drug 39 (1) : 86 ~ 109
Chun MK / 2003 / Preparation of buccal patch composed of carbobol, poloxamer and hydroxypropyl methylcellulose / Arch Pharm Res 26 (11) : 973 ~ 978
Grandos-Soto V / 1995 / Evidence against the participation of μ-and -opioid receptors in the analgesic activity of ketorolac in rats / J Pharm Pharmacol 47 (6) : 514 ~ 517
Jeffcoat MK / 1995 / A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis / J Periodontol 66 (5) : 529
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