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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 46 - 50 (5page)
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초록· 키워드
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Background/Aims: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). Methods: GERD was created in rats by tying the proximal stomach. The rats were divided into a control group, a proton pump inhibitor (PPI) group, and a PPI plus rebamipide (PPI+R) group. Pantoprazole (5 mg/kg) was administered intraperitoneally to the PPI and PPI+R groups. An additional dose of rebamipide (100 mg/kg) was administered orally to the PPI+R group. Mucosal erosions, epithelial thickness, and leukocyte infiltration into the esophageal mucosa were measured in isolated esophagi 14 days after the procedure. A Western blot analysis was conducted to measure the expression of claudin-1, -3, and -4. Results: The mean surface area of mucosal erosions, epithelial thickness, and leukocyte infiltration were lower in the PPI group and the PPI+R group than in the control group. Western blot analysis revealed that the expression of claudin-3 and -4 was significantly higher in the PPI+R group than in the control group. Conclusions: Rebamipide may exert an additive effect in combination with PPI to modify the tight junction proteins of the esophageal mucosa in a rat model of GERD. This treatment might be associated with the relief of GERD symptoms.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Vakil N / 2006 / The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus / Am J Gastroenterol 101:1900~1920
Farre R / 2008 / Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces / Gut 57:1366~1374
van Malenstein H / 2008 / Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease / Am J Gastroenterol 103:1021~1028
Caviglia R / 2005 / Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure / Am J Gastroenterol 100:543~548
Tobey NA / 1996 / Dilated intercellular spaces: a morphological feature of acid reflux--damaged human esophageal epithelium / Gastroenterology 111:1200~1205
Farre R / 2008 / Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces / Gut 57:1366~1374
van Malenstein H / 2008 / Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease / Am J Gastroenterol 103:1021~1028
Caviglia R / 2005 / Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure / Am J Gastroenterol 100:543~548
Tobey NA / 1996 / Dilated intercellular spaces: a morphological feature of acid reflux--damaged human esophageal epithelium / Gastroenterology 111:1200~1205
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