지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.2
- 발행연도
- 2018.1
- 수록면
- 182 - 196 (15page)
이용수
초록· 키워드
오류제보하기
Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases including gastroesophageal reflux disease and secondary prevention of aspirin/NSAID-induced ulcers. Although clinically important adverse effects of PPIs can occur, just as with other drugs, those are not frequently observed during or after administration. Thus, PPIs are regarded as relatively safe and considered to be clinically beneficial. Recently, PPIs have become frequently administered to patients with functional gastrointestinal diseases or primary prevention of drug-related gastroduodenal damage, even though their beneficial effects for those conditions have not been fully confirmed. PPIs tend to be given for conditions in which the necessity of the drug has not been clarified, thus otherwise rare adverse effects are presented as clinically relevant. Although several PPI-related adverse effects have been reported, their clinical relevance is not yet clear, since the evidence reported in those studies is not at a high enough level, as the majority are based on retrospective observational studies and the reported hazard ratios are low. It is important to administer PPIs only for patients who will gain a substantial clinical benefit and to continue to investigate their adverse effects with high quality prospective studies.
목차
등록된 정보가 없습니다.
참고문헌 (155)
참고문헌 신청
Komazawa Y / 2003 / Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection / J Gastroenterol Hepatol 18:678~682
Iwakiri K / 2016 / Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015 / J Gastroenterol 51:751~767
Lanas A / 2016 / We are using too many PPIs, and we need to stop: a European perspective / Am J Gastroenterol 111:1085~1086
Fujisawa T / 2004 / Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists / Aliment Pharmacol Ther 20:559~565
Adachi K / 2005 / Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine / J Gastroenterol Hepatol 20:1012~1015
Iwakiri K / 2016 / Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015 / J Gastroenterol 51:751~767
Lanas A / 2016 / We are using too many PPIs, and we need to stop: a European perspective / Am J Gastroenterol 111:1085~1086
Fujisawa T / 2004 / Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists / Aliment Pharmacol Ther 20:559~565
Adachi K / 2005 / Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine / J Gastroenterol Hepatol 20:1012~1015
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