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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 835 - 842 (8page)
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Background/Aims: The introduction of direct-acting antivirals (DAA) in 2013 revolutionized hepatitis C virus (HCV) treatment, offering a cure rate >90%. However, this therapy is expensive, and estimations of the number of chronic HCV-infected (CHC) patients and their treatment costs pre-2013 are therefore essential for creating policies and expanding drug access. Herein, we aimed to investigate the number of HCV-related liver disease patients, their healthcare utilization, their annual direct medical costs, and the interferon-based antiviral treatment rates and costs from 2009 to 2013 in South Korea. Methods: The National Health Insurance database was reviewed, and patients diagnosed with CHC from 2009 to 2013 were extracted. Data regarding detailed healthcare utilization, prescribed drugs, and direct medical costs were obtained. For annual direct healthcare cost calculations, a prevalence-based approach was used. Results: Overall, 181,768 CHC patients were identified. In 2013, the annual per-patient costs for chronic hepatitis, liver cirrhosis, hepatocellular carcinoma, and the first year post-liver transplant were 895, 1,873, 6,945, and 67,359 United States dollars, respectively. Interferon-based antiviral therapeutics were prescribed to 25,223 patients (13.9%). Conclusions: Healthcare costs have increased remarkably with increasing liver disease severity. Thus, efforts to stop disease progression are needed. Moreover, the low rate of interferon-based therapy indicates an unmet need for DAA.
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참고문헌 (18)
참고문헌 신청
Cox AL / 2015 / MEDICINE: global control of hepatitis C virus / Science 349 : 790 ~ 791
Honegger JR / 2014 / Will there be a vaccine to prevent HCV infection / Semin Liver Dis 34 : 79 ~ 88
Hsu PC / 2012 / Health utilities and psychometric quality of life in patients with early- and late-stage hepatitis C virus infection / J Gastroenterol Hepatol 27 : 149 ~ 157
Jo C / 2014 / Cost-of-illness studies: concepts, scopes, and methods / Clin Mol Hepatol 20 : 327 ~ 337
Kim DY / 2013 / A nationwide seroepidemiology of hepatitis C virus infection in South Korea / Liver Int 33 : 586 ~ 594
Honegger JR / 2014 / Will there be a vaccine to prevent HCV infection / Semin Liver Dis 34 : 79 ~ 88
Hsu PC / 2012 / Health utilities and psychometric quality of life in patients with early- and late-stage hepatitis C virus infection / J Gastroenterol Hepatol 27 : 149 ~ 157
Jo C / 2014 / Cost-of-illness studies: concepts, scopes, and methods / Clin Mol Hepatol 20 : 327 ~ 337
Kim DY / 2013 / A nationwide seroepidemiology of hepatitis C virus infection in South Korea / Liver Int 33 : 586 ~ 594
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