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논문 기본 정보

자료유형
학술저널
저자정보
Jang Eun Sun (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Kim Kyung-Ah (Department of Internal Medicine Inje University Ilsan Paik Hospital Goyang Korea) Kim Young Seok (Department of Internal Medicine Soonchunhyang University Bucheon Hospital Soonchunhyang University) Kim In Hee (Department of Internal Medicine Chonbuk National University Hospital Chonbuk National University Me) Lee Byung Seok (Chungnam National University) Lee Youn Jae (Department of Internal Medicine Inje University Busan Paik Hospital Inje University College of Medi) Chung Woo Jin (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea.) Jeong Sook-Hyang (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제14권 제6호
발행연도
2020.1
수록면
775 - 782 (8page)

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Background/Aims: Sofosbuvir (SOF)-based therapy has been used in Korean patients with chronic hepatitis C virus (HCV) infection since January 2016. This study aimed to investigate the real-life effectiveness and safety of SOF-based therapy in genotype 2 HCV infection. Methods: From January to December 2016, 458 genotype 2 HCV-infected patients who received ≥1 dose of SOF-based therapy were consecutively enrolled in seven tertiary hospitals. Sustained virologic response (SVR) rates and safety were determined by intention- to-treat (ITT) and per-protocol (PP) analyses. Results: The mean age of the patients was 61.0 years; 183 (40%) were male, and 13.1% showed a high viral load (>6,000,000 IU/ mL). Among the 378 treatment-naive patients, the SVR rates were 94.2% (ITT) and 96.7% (PP). Among the 80 treatmentexperienced patients, the SVR rates were 96.3% (ITT) and 98.7% (PP). Patients with a relatively high fibrosis-4 index score (>3.25) had similar SVR rates to those with a relatively low score (p=0.756). A total of 314 patients (68.6%) were treated with a reduced ribavirin dose at the prescriber’s discretion, but they showed similar SVR rates to those treated with the weight-based dose (ITT: 95.5% and 92.3%, PP: 97.4% and 96.3%, respectively). Adverse events were observed in 191 patients (41.7%), including 86 (18.8%) with anemia, but only one (0.2%) discontinued antiviral therapy due to nausea. Conclusions: SOF-based therapy showed high real-life efficacy and tolerability in Korean patients with genotype 2 chronic HCV infection, regardless of previous antiviral treatment experience and fibrosis score. A reduced ribavirin dose can be considered in this patient cohort.
#Hepatitis C #Chronic #Sofosbuvir #Ribavirin #Genotype 2

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참고문헌 (31)

참고문헌 신청
Mohd Hanafiah K / 2013 / Global epidemiology of hepatitis C virus infection : new estimates of age-specific antibody to HCV seroprevalence / Hepatology 57:1333~1342 google schola Stanaway JD / 2016 / The global burden of viral hepatitis from 1990 to 2013 : findings from the Global Burden of Disease Study 2013 / Lancet 388:1081~1088 google schola Kim DY / 2013 / A nationwide seroepidemiology of hepatitis C virus infection in South Korea / Liver Int 33:586~594 google schola Sang Soo Lee / 2012 / Type and cause of liver disease in Korea: single-center experience, 2005-2010 / Clinical and Molecular Hepatology 18(3):309~315 dbpia Seong MH / 2013 / Clinical and epidemiological features of hepatitis C virus infection in South Korea : a prospective, multicenter cohort study / J Med Virol 85:1724~1733 google schola

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