지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 549 - 556 (8page)
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Background/Aims: Patients with Hansen’s disease are the most vulnerable to hepatitis C. However, no data on the treatment efficacy of direct-acting antiviral agents (DAAs) are available in this group. Therefore, we elucidated the prevalence and clinical outcomes of hepatitis C in persons affected by leprosy in Sorokdo, Jeollanam-do, Korea. Methods: We retrospectively included 50 leprosy patients with positive hepatitis C virus (HCV) RNA test results (group A) hospitalized at the Sorokdo National Hospital from May 2016 to March 2018 and 73 patients with chronic hepatitis C who were treated with DAAs at the Chonnam National University Hospital (group B) from May 2016 to December 2017. Results: Overall, at the Sorokdo National Hospital, positive HCV antibody and HCV RNA rates were 18.4% and 11.0%, respectively. The mean participant age was 76.5±7 years, and 58% of participants were men. The genotypes were type 1b in 44% (22 out of 50) and type 2 in 56% (28 out of 50). Sustained virologic response was achieved at a rate of 95.5% (21/22) in genotype 1b and 92.9% (26/28) in genotype 2 patients. Ribavirin-induced hemolytic anemia occurred in 57.1% (16/28) of patients with genotype 2. Among these, 28.5% (8/28) received blood transfusions. Conclusions: Treatment efficacy was not different between the leprosy-affected population and the general population. However, severe ribavirin-induced hemolytic anemia requiring transfusion was present in 28.5% of genotype 2 patients. Therefore, we suggest ribavirin-free DAAs for the treatment of genotype 2 hepatitis C in leprosy-affected persons in the future.
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참고문헌 (41)
참고문헌 신청
Polaris Observatory HCV Collaborators / 2017 / Global prevalence and genotype distribution of hepatitis C virus infection in 2015 : a modelling study / Lancet Gastroenterol Hepatol 2:161~176
Hu KQ / 1999 / The long-term outcomes of patients with compensated hepatitis C virus-related cirrhosis and history of parenteral exposure in the United States / Hepatology 29:1311~1316
Fattovich G / 1997 / Morbidity and mortality in compensated cirrhosis type C : a retrospective follow-up study of 384 patients / Gastroenterology 112:463~472
Westbrook RH / 2014 / Natural history of hepatitis C / J Hepatol 61:S58
Petruzziello A / 2018 / Epidemiology of hepatitis B virus(HBV)and hepatitis C virus(HCV)related hepatocellular carcinoma / Open Virol J 12:26~32
Hu KQ / 1999 / The long-term outcomes of patients with compensated hepatitis C virus-related cirrhosis and history of parenteral exposure in the United States / Hepatology 29:1311~1316
Fattovich G / 1997 / Morbidity and mortality in compensated cirrhosis type C : a retrospective follow-up study of 384 patients / Gastroenterology 112:463~472
Westbrook RH / 2014 / Natural history of hepatitis C / J Hepatol 61:S58
Petruzziello A / 2018 / Epidemiology of hepatitis B virus(HBV)and hepatitis C virus(HCV)related hepatocellular carcinoma / Open Virol J 12:26~32
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