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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제19권 제2호
- 발행연도
- 2016.1
- 수록면
- 83 - 95 (13page)
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초록· 키워드
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Hepatitis C virus (HCV) infection is a major medical challenge affecting around 200 million people worldwide. The main site of HCV replication is the hepatocytes of the liver. HCV is a positive enveloped RNA virus from the flaviviridae family. Six major HCV genotypes are implicated in the human infection. In developed countries the children are in-fected mainly through vertical transmission during deliveries, while in developing countries it is still due to horizontal transmission from adults. Minimal nonspecific and brief symptoms are initially found in approximately 15% of children. Acute and chronic HCV infection is diagnosed through the recognition of HCV RNA. The main objective for treatment of chronic HCV is to convert detected HCV viremia to below the detection limit. Children with chronic HCV infection are usually asymptomatic and rarely develop severe liver damage. Therefore, the benefits from current therapies, pegylated-Interferon plus ribavirin, must be weighed against their adverse effects. This combined treatment offers a 50-90% chance of clearing HCV infection according to several studies and on different HCV genotype. Recent direct acting antiviral (DAA) drugs which are well established for adults have not yet been approved for children and young adults below 18 years. The most important field for the prevention of HCV infection in children would be the prevention of perinatal and parenteral transmission. There are areas of focus for new lines of research in pediatric HCV-related disease that can be addressed in the near future.
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참고문헌 (90)
참고문헌 신청
Choo QL / 1989 / Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome / Science 244:359~362
Messina JP / 2015 / Global distribution and prevalence of hepatitis C virus genotypes / Hepatology 61:77~87
Jhaveri R / 2011 / Diagnosis and management of hepatitis C virus- infected children / Pediatr Infect Dis J 30:983~985
El-Raziky MS / 2007 / Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children / World J Gastroenterol 13:1828~1832
Baré P / 2009 / Hepatitis C virus and peripheral blood mononuclear cell reservoirs Patricia Baré / World J Hepatol 1:67~71
Messina JP / 2015 / Global distribution and prevalence of hepatitis C virus genotypes / Hepatology 61:77~87
Jhaveri R / 2011 / Diagnosis and management of hepatitis C virus- infected children / Pediatr Infect Dis J 30:983~985
El-Raziky MS / 2007 / Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children / World J Gastroenterol 13:1828~1832
Baré P / 2009 / Hepatitis C virus and peripheral blood mononuclear cell reservoirs Patricia Baré / World J Hepatol 1:67~71
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