Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea

Lim Dae Hyun; Jeong Jae Yoon; Nam Seongwoo; Choi Jongkyoung; Kwon Hyeok Choon; Yoon Yong Bum; Kim Yeonjae; Chin BumSik

doi:10.3346/jkms.2021.36.e308

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자료유형: 학술저널

저자정보: Lim Dae Hyun (Division of Gastroenterology and Hepatology Department of Internal Medicine National Medical Center) Jeong Jae Yoon (Division of Gastroenterology and Hepatology Department of Internal Medicine National Medical Center) Nam Seongwoo (Division of Gastroenterology and Hepatology Department of Internal Medicine National Medical Center) Choi Jongkyoung (Division of Gastroenterology and Hepatology Department of Internal Medicine National Medical Center) Kwon Hyeok Choon (Division of Gastroenterology and Hepatology Department of Internal Medicine National Medical Center) Yoon Yong Bum (Division of Gastroenterology and Hepatology Department of Internal Medicine National Medical Center) Kim Yeonjae (Division of Infectious Diseases Department of Internal Medicine National Medical Center Seoul Korea) Chin BumSik (Division of Infectious Diseases Department of Internal Medicine National Medical Center Seoul Korea)

저널정보: 대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.46

발행연도: 2021.11

수록면: 1 - 11 (11page)

DOI: 10.3346/jkms.2021.36.e308

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Background: Because of the very low incidence of human immunodeficiency virus (HIV) coinfection in Korea, data on hepatitis C virus (HCV)/HIV coinfection are limited. This study aimed to investigate the clinical characteristics and treatment outcomes of patients with HCV/HIV coinfection in Korea. Methods: We performed a retrospective cohort study of all HCV-monoinfected and HCV/ HIV-coinfected patients treated with antivirals at National Medical Center in Seoul, Korea, between January 2009 and March 2020. Results: We enrolled 220 HCV-monoinfected and 23 HCV/HIV-coinfected patients treated with antivirals. The HCV/HIV-coinfected patients were younger (HCV vs. HCV/HIV: 57.3 ± 11.3 vs. 40.7 ± 10.1 years, P < 0.001) and had a higher proportion of men (HCV vs. HCV/ HIV: 54.5% [n = 120] vs. 91.3% [n = 21], P < 0.001) than the HCV-monoinfected patients. Genotype 1b and 2 were most common in both HCV monoinfection and HCV/HIV coinfection groups. HCV-monoinfected patients had a higher incidence of genotype 1b and 2 than HCV/HIV-coinfected patients (HCV vs. HCV/HIV: 95.4% [n = 210] vs. 73.9% [n = 17], P < 0.001), while the HCV/HIV-coinfected patients had genotype 1a (HCV vs. HCV/HIV: 1.8% [n = 4] vs. 21.7% [n = 5], P < 0.001). The fibrosis-4 index was significantly lower in the HCV/ HIV-coinfected patients than in the HCV-monoinfected patients (HCV vs. HCV/HIV: 3.81 ± 3.38 vs. 1.66 ± 1.10, P < 0.001). Among the direct-acting antivirals (DAA)-treated patients, the sustained viral response (SVR) rate did not differ significantly between both groups (HCV vs. HCV/HIV: 94.9% [93/99] vs. 90.9% [10/11], P = 0.480). Conclusion: In Korea, the HCV/HIV-coinfected patients who received antiviral treatment were younger, had higher proportion of men and incidence of genotype 1a, and had less advanced fibrosis than the HCV-monoinfected patients. In actual clinical settings, HCV/HIV-coinfected patients show excellent SVR to DAA treatment, similar to HCVmonoinfected patients.

#Hepatitis C Virus #Human Immunodeficiency Virus #Direct-Acting Antivirals

참고문헌 (25)

참고문헌 신청

Messina JP / 2015 / Global distribution and prevalence of hepatitis C virus genotypes / Hepatology 61(1):77~87

정숙향 / 2017 / Current status of hepatitis C virus infection and countermeasures in South Korea / Epidemiology and Health 39:1~7

Kyung-Ah Kim / 2020 / Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey / Gut and Liver 14(5):644~651

World Health Organization / Global progress report on HIV, viral hepatitis and sexually transmitted infections

Utsumi T / 2015 / Viral hepatitis and human immunodeficiency virus co-infections in Asia / World J Virol 4(2):96~104

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