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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 508 - 515 (8page)
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초록· 키워드
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Background/Aims: Syndecan-2 (SDC2 ) methylation was previously reported as a sensitive serologic biomarker for the early detection of colorectal cancer (CRC). The purpose of this study was to investigate whether SDC2 methylation is detectable in precancerous lesions and to determine the feasibility of using SDC2 methylation for the detection of CRC and precancerous lesions in bowel lavage fluid (BLF). Methods: A total of 190 BLF samples were collected from the rectum at the beginning of colonoscopy from patients with colorectal neoplasm and healthy normal individuals. Fourteen polypectomy specimens were obtained during colonoscopy. A bisulfite pyrosequencing assay and quantitative methylation-specific polymerase chain reaction were conducted to measure SDC2 methylation in tissues and BLF DNA. Results: SDC2 methylation was positive in 100% of villous adenoma (VA) and high-grade dysplasia, and hyperplastic polyp samples; 88.9% of tubular adenoma samples; and 0% of normal mucosa samples. In the BLF DNA test for SDC2 methylation, the sensitivity for detecting CRC and VA was 80.0% and 64.7%, respectively, at a specificity of 88.9%. The BLF of patients with multiple tubular adenomas, single tubular adenoma and hyperplastic polyps showed 62.8%, 26.7% and 28.6% rates of methylation-positive SDC2, respectively. Conclusions: Our results demonstrated that SDC2 methylation was a frequent event in precancerous lesions and showed high potential in BLF for detecting patients with colorectal neoplasm.
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참고문헌 (34)
참고문헌 신청
Jemal A / 2010 / Cancer statistics, 2010 / CA Cancer J Clin 60:277~300
Meissner HI / 2006 / Patterns of colorectal cancer screening uptake among men and women in the United States / Cancer Epidemiol Biomarkers Prev 15:389~394
Ahluwalia IB / 2003 / Statespecific prevalence of selected chronic disease-related characteristics: Behavioral Risk Factor Surveillance System, 2001 / MMWR Surveill Summ 52:1~80
Duffy MJ / 2003 / Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines / Eur J Cancer 39:718~727
Harada T / 2014 / Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer / Cancer Prev Res (Phila) 7:1002~1010
Meissner HI / 2006 / Patterns of colorectal cancer screening uptake among men and women in the United States / Cancer Epidemiol Biomarkers Prev 15:389~394
Ahluwalia IB / 2003 / Statespecific prevalence of selected chronic disease-related characteristics: Behavioral Risk Factor Surveillance System, 2001 / MMWR Surveill Summ 52:1~80
Duffy MJ / 2003 / Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines / Eur J Cancer 39:718~727
Harada T / 2014 / Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer / Cancer Prev Res (Phila) 7:1002~1010
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