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자료유형
학술저널
저자정보
신철민 (분당서울대학교병원) 김나영 (서울대학교병원) 윤혁 (분당서울대학교병원) 최윤진 (연세대학교) 박지현 (분당서울대학교병원) 박영수 (분당서울대학교병원) 이동호 (서울대학교병원)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제54권 제4호
발행연도
2022.10
수록면
1,157 - 1,166 (10page)
DOI
10.4143/crt.2021.997

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Purpose This study aimed to investigate whether <i>MOS</i> methylation can be useful for the prediction of metachronous recurrence after endoscopic resection of gastric neoplasms.Materials and Methods From 2012 to 2017, 294 patients were prospectively enrolled after endoscopic resection of gastric dysplasia (n=171) or early gastric cancer (n=123). When <i>Helicobacter pylori</i> was positive, eradication therapy was performed. Among them, 124 patients completed the study protocol (follow-up duration > 3 years or development of metachronous recurrence during the follow-up). Methylation levels of <i>MOS</i> were measured at baseline using quantitative MethyLight assay from the antrum.Results Median follow-up duration was 49.9 months. <i>MOS</i> methylation levels at baseline were not different by age, sex, and current <i>H. pylorii</i> infection, but they showed a weak correlation with operative link on gastritis assessment (OLGA) or operative link on gastric intestinal metaplasia assessment (OLGIM) stages (Spearman’s ρ=0.240 and 0.174, respectively; p < 0.05). During the follow-up, a total of 20 metachronous gastric neoplasms (13 adenomas and 7 adenocarcinomas) were developed. Either OLGA or OLGIM stage was not useful in predicting the risk for metachronous recurrence. In contrast, <i>MOS</i> methylation high group (≥ 34.82%) had a significantly increased risk for metachronous recurrence compared to <i>MOS</i> methylation low group (adjusted hazard ratio, 4.76; 95% confidence interval, 1.54 to 14.79; p=0.007).Conclusion <i>MOS</i> methylation can be a promising marker for predicting metachronous recurrence after endoscopic resection of gastric neoplasms. To confirm the usefulness of <i>MOS</i> methylation, validation studies are warranted in the future (ClinicalTrials No. NCT04830618).

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