지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 607 - 614 (8page)
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초록· 키워드
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Background/Aims: Proton pump inhibitors (PPIs) act by irreversibly binding to the H+-K+-ATPase of the proton pump in parietal cells and may possibly affect the vacuolar H+-ATPase in osteoclasts. Methods: We investigated the effect of 8 weeks of PPI treatment on the parameters of bone turnover and compared PPI with revaprazan, which acts by reversibly binding to H+-K+-ATPase in proton pumps. This study was a parallel randomized controlled trial. For 8 weeks, either a PPI or revaprazan was randomly assigned to patients with gastric ulcers. The parameters of bone turnover were measured at the beginning of and after the 8-week treatment period. Results: Twenty-six patients (PPI, n=13; revaprazan, n=13) completed the intention-to-treat analysis. After the 8-week treatment period, serum calcium and urine deoxypyridinoline (DPD) were increased in the PPI group (serum calcium, p=0.046; urine DPD, p=0.046) but not in the revaprazan group. According to multivariate linear regression analysis, age ≥60 years was an independent predictor for the changes in serum calcium and urine DPD. Conclusions: In elderly patients, administering a PPI for 8 weeks altered bone parameters. Our study suggested that PPIs might directly alter bone metabolism via the vacuolar H+-ATPase in osteoclasts.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Chonan O / 1998 / Effect of L-lactic acid on calcium absorption in rats fed omeprazole / J Nutr Sci Vitaminol 44 : 473 ~ 481
Dhonukshe-Rutten RA / 2003 / Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men / J Nutr 133 : 801 ~
Gagnemo-Persson R / 1994 / Growth of the parathyroid glands in omeprazole-treated chickens / Scand J Gastroenterol 29 : 493 ~ 497
Gagnemo-Persson R / 1997 / Chicken parathyroid hormone gene expression in response to gastrin, omeprazole, ergocalciferol, and restricted food intake / Calcif Tissue Int 61
Hansen KE / 2010 / Do proton pump inhibitors decrease calcium absorption? / J Bone Miner Res 25 : 2786 ~ 2795
Dhonukshe-Rutten RA / 2003 / Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men / J Nutr 133 : 801 ~
Gagnemo-Persson R / 1994 / Growth of the parathyroid glands in omeprazole-treated chickens / Scand J Gastroenterol 29 : 493 ~ 497
Gagnemo-Persson R / 1997 / Chicken parathyroid hormone gene expression in response to gastrin, omeprazole, ergocalciferol, and restricted food intake / Calcif Tissue Int 61
Hansen KE / 2010 / Do proton pump inhibitors decrease calcium absorption? / J Bone Miner Res 25 : 2786 ~ 2795
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