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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제20권 제1호
- 발행연도
- 2015.1
- 수록면
- 21 - 26 (6page)
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Purpose: Glycosylated hemoglobin (HbA1c) is often used as an indicator of glucose control. It usually reflects the average glucose levels over two to three months, and is correlated with the development of long-term diabetic complications. However, it can vary in cases of hemoglobinopathy or an altered red blood cell lifespan. The serum fructosamine levels reflect the mean glucose levels over two to three weeks.
This study was designed to determine the clinical usefulness of the combined measurement of serum fructosamine and HbA1c in the management of childhood diabetes mellitus and the correlation between them.
Methods: Clinical data on 74 Korean children and adolescents with diabetes mellitus who were under management at the Department of Pediatrics of Dankook University Hospital were evaluated. Their fructosamine and HbA1c levels were reviewed based on clinical information, and analyzed using IBM SPSS Statistics ver.
21.
Results: Their HbA1c levels showed a strong correlation with their fructosamine levels (r=0.868, P<0.001). The fructosamine level was useful for the prompt evaluation of the recent therapeutic efficacy after the change in therapeutic modality. It was also profitable in determining the initial therapeutics and for the estimation of the onset of the disease, such as fulminant diabetes.
Conclusion: The measurement of both fructosamine and HbA1c was useful in managing childhood diabetes mellitus, especially when there was discrepancy between the clinical information and the HbA1c level.
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참고문헌 (40)
참고문헌 신청
Bry L / 2001 / Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin / Clin Chem 47:153~163
Eschbach JW. / 1989 / The anemia of chronic renal failure:pathophysiology and the effects of recombinant erythropoietin / Kidney Int 35:134~148
Ly J / 2004 / Red blood cell survival in chronic renal failure / Am J Kidney Dis 44:715~719
Derr R / 2003 / Is HbA(1c)affected by glycemic instability? / Diabetes Care 26:2728~2733
Ceriello A. / 2005 / Postprandial hyperglycemia and diabetes complications: is it time to treat? / Diabetes 54:1~7
Eschbach JW. / 1989 / The anemia of chronic renal failure:pathophysiology and the effects of recombinant erythropoietin / Kidney Int 35:134~148
Ly J / 2004 / Red blood cell survival in chronic renal failure / Am J Kidney Dis 44:715~719
Derr R / 2003 / Is HbA(1c)affected by glycemic instability? / Diabetes Care 26:2728~2733
Ceriello A. / 2005 / Postprandial hyperglycemia and diabetes complications: is it time to treat? / Diabetes 54:1~7
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