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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제22권 제1호
- 발행연도
- 2017.1
- 수록면
- 36 - 42 (7page)
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Purpose: The most common single nucleotide polymorphism in the IGFBP3 promoter region occurs at position -202. This polymorphic variation occurs frequently and may influence growth hormone responsiveness and somatic growth. However, the effects of IGFBP3 promoter polymorphism on growth in children are unknown. Methods: Restriction fragment length polymorphism-based genotyping of the -202 single nucleotide polymorphism was performed in 146 Korean girls aged between 15 and 16 years, who were selected randomly from the Seoul School Health Promotion Center. The participants were divided into 3 groups (tall, medium, and short) according to the height percentile established from normal reference values for Korean children. The serum levels of insulin-like growth factor I (IGF-I) and IGFbinding protein-3 (IGFBP-3) were then compared according to genotype. Results: The genotype distribution in the participants was 79 AA (54.1%), 60 AC (41.1%), and 7 CC (4.8%). The C allele frequency at the -202 IGFBP3 position was 25.4% in this group. The mean serum IGFBP-3 concentration in girls with the AA genotype was higher than that in girls with the AC genotype in the medium (P=0.047) and short (P=0.035) groups, respectively. There was no difference in the IGF-I to IGFBP-3 molar ratio between the AA and AC genotype groups (P=0.161). Conclusion: In conclusion, the -202 polymorphism in the IGFBP3 promoter region is assumed to affect the serum concentration of IGFBP-3 in children as well as in adults. However, it is unclear whether this affects physical development according to the concentration of IGFBP-3.
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참고문헌 (20)
참고문헌 신청
Al-Zahrani A / 2006 / IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer / Hum Mol Genet 15 : 1 ~ 10
Blum WF / 1993 / Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion / J Clin Endocrinol Metab 76 : 16
Chan JM / 1998 / Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study / Science 279 : 563 ~ 566
Choi WJ / 2006 / the relationship between insulin-like growth factor binding protein-3 promoter polymorphism and growth / J Korean Soc Pediatr Endocrinol 11 : 28 ~ 32
Daughaday WH / 1989 / Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations / Endocr Rev 10 : 68 ~ 9
Blum WF / 1993 / Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion / J Clin Endocrinol Metab 76 : 16
Chan JM / 1998 / Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study / Science 279 : 563 ~ 566
Choi WJ / 2006 / the relationship between insulin-like growth factor binding protein-3 promoter polymorphism and growth / J Korean Soc Pediatr Endocrinol 11 : 28 ~ 32
Daughaday WH / 1989 / Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations / Endocr Rev 10 : 68 ~ 9
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