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논문 기본 정보
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- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제20권 제2호
- 발행연도
- 2015.1
- 수록면
- 69 - 73 (5page)
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Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
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참고문헌 (22)
참고문헌 신청
Baxter RC / 1989 / Binding proteins for the insulin-like growth factors: structure, regulation and function / Prog Growth Factor Res 1 : 49 ~ 68
Clemmons DR. / 2006 / Involvement of insulin-like growth factor-I in the control of glucose homeostasis / Curr Opin Pharmacol 6 : 620 ~ 625
Daughaday WH. / 1990 / The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors / Endocrinology 127 : 1 ~ 4
Jacob R / 1989 / Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin / J Clin Invest 83 : 171
Jogie-Brahim S / 2009 / Unraveling insulin-like growth factor binding protein-3 actions in human disease / Endocr Rev 30 : 417 ~ 437
Clemmons DR. / 2006 / Involvement of insulin-like growth factor-I in the control of glucose homeostasis / Curr Opin Pharmacol 6 : 620 ~ 625
Daughaday WH. / 1990 / The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors / Endocrinology 127 : 1 ~ 4
Jacob R / 1989 / Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin / J Clin Invest 83 : 171
Jogie-Brahim S / 2009 / Unraveling insulin-like growth factor binding protein-3 actions in human disease / Endocr Rev 30 : 417 ~ 437
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