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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제23권 제4호
- 발행연도
- 2018.1
- 수록면
- 210 - 214 (5page)
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초록· 키워드
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Purpose: Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5–8 years) and age and body mass index (BMI) matched controls. Methods: Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done. Results: PA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/ m2). Dehydroepiandrostenedione sulfate (63.3±51.3 µg/dL vs. 29.8±17.3 µg/dL, P<0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49–3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups. Conclusion: Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.
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참고문헌 (39)
참고문헌 신청
Leung AK / 2008 / Premature adrenarche / J Pediatr Health Care 22:230~233
Liimatta J / 2014 / Serum androgen bioactivity is low in children with premature adrenarche / Pediatr Res 75:645~650
Voutilainen R / 2015 / Premature adrenarche:etiology, clinical findings, and consequences / J Steroid Biochem Mol Biol 145:226~236
Montalto J / 1989 / Serum 5-androstene-3 beta,17 beta-diol sulphate, sex hormone binding globulin and free androgen index in girls with premature adrenarche / J Steroid Biochem 33:1149~1154
Dorn LD / 2008 / Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche / J Pediatr Endocrinol Metab 21:439~448
Liimatta J / 2014 / Serum androgen bioactivity is low in children with premature adrenarche / Pediatr Res 75:645~650
Voutilainen R / 2015 / Premature adrenarche:etiology, clinical findings, and consequences / J Steroid Biochem Mol Biol 145:226~236
Montalto J / 1989 / Serum 5-androstene-3 beta,17 beta-diol sulphate, sex hormone binding globulin and free androgen index in girls with premature adrenarche / J Steroid Biochem 33:1149~1154
Dorn LD / 2008 / Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche / J Pediatr Endocrinol Metab 21:439~448
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