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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 401 - 412 (12page)
이용수
초록· 키워드
오류제보하기
Background: Guidelines by the Endocrine Society Guideline on bypassing adrenal vein sampling (AVS) in patients <35 years oldwith marked primary aldosteronism (PA) (hypokalemia and elevated plasma aldosterone concentration [PAC]) and a unilateral lesion on computed tomography (CT) are based on limited number of studies. We aimed to determine the accuracy of CT in PA patients according to age. Methods: In this retrospective study, we investigated the concordance between CT and AVS in 466 PA patients from two tertiarycenters who successfully underwent AVS. Results: CT had an overall accuracy of 64.4% (300/466). In the group with unilateral lesion, patients with hypokalemia had higherconcordance than those without hypokalemia (85.0% vs. 43.6%, P<0.001). In the group with marked PA (hypokalemia and PAC>15.9 ng/dL) and unilateral lesion, accuracy of CT was 84.6% (11/13) in patients aged <35 years; 100.0% (20/20), aged 35 to 39years; 89.4% (59/66), aged 40 to 49 years; and 79.8% (79/99), aged ≥50 years. Cut-off age and PAC for concordance was <50years and >29.6 ng/dL, respectively. The significant difference in accuracy of CT in 198 patients with marked PA and a unilateral lesion between the <50-year age group and ≥50-year age group (90.9% vs. 79.8%, P=0.044) disappeared in 139 of 198 patients withPAC > 30.0 ng/dL (91.9% vs. 87.7%, P=0.590). Conclusion: Patients with hypokalemia, PAC >30.0 ng/dL, and unilateral lesion were at high risk of unilateral PA regardless of age.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Funder JW / 2016 / The management of primary aldosteronism : case detection, diagnosis, and treatment : an endocrine society clinical practice guideline / J Clin Endocrinol Metab 101:1889~1916
Mulatero P / 2013 / Long-term cardio-and cerebrovascular events in patients with primary aldosteronism / J Clin Endocrinol Metab 98:4826~4833
Reincke M / 2012 / Observational study mortality in treated primary aldosteronism : the German Conn’s registry / Hypertension 60:618~624
Savard S / 2013 / Cardiovascular complications associated with primary aldosteronism : a controlled cross-sectional study / Hypertension 62:331~336
Monticone S / 2015 / Adrenal vein sampling in primary aldosteronism : towards a standardised protocol / Lancet Diabetes Endocrinol 3:296~303
Mulatero P / 2013 / Long-term cardio-and cerebrovascular events in patients with primary aldosteronism / J Clin Endocrinol Metab 98:4826~4833
Reincke M / 2012 / Observational study mortality in treated primary aldosteronism : the German Conn’s registry / Hypertension 60:618~624
Savard S / 2013 / Cardiovascular complications associated with primary aldosteronism : a controlled cross-sectional study / Hypertension 62:331~336
Monticone S / 2015 / Adrenal vein sampling in primary aldosteronism : towards a standardised protocol / Lancet Diabetes Endocrinol 3:296~303
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