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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제23권 제4호
- 발행연도
- 2018.1
- 수록면
- 196 - 203 (8page)
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Purpose: The hemoglobin glycation index (HGI) represents the degree of nonenzymatic glycation and has been positively associated with cardiometabolic risk factors (CMRFs) and cardiovascular disease in adults. This study aimed to investigate the association between HGI, components of metabolic syndrome (MS), and alanine aminotransferase (ALT) in a pediatric nondiabetic population. Methods: Data from 3,885 subjects aged 10–18 years from the Korea National Health and Nutrition Examination Survey (2011–2016) were included. HGI was defined as subtraction of predicted glycated hemoglobin (HbA1c) from measured HbA1c. Participants were divided into 3 groups according to HGI tertile. Components of MS (abdominal obesity, fasting glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure), and proportion of MS, CMRF clustering (≥2 of MS components), and elevated ALT were compared among the groups. Results: Body mass index (BMI) z-score, obesity, total cholesterol, ALT, abdominal obesity, elevated triglycerides, and CMRF clustering showed increasing HGI trends from lower-to-higher tertiles. Multiple logistic regression analysis showed the upper HGI tertile was associated with elevated triglycerides (odds ratio, 1.65; 95% confidence interval, 1.18–2.30). Multiple linear regression analysis showed HGI level was significantly associated with BMI z-score, HbA1c, triglycerides, and ALT. When stratified by sex, age group, and BMI category, overweight/obese subjects showed linear HGI trends for presence of CMRF clustering and ALT elevation. Conclusion: HGI was associated with CMRFs in a Korean pediatric population. High HGI might be an independent risk factor for CMRF clustering and ALT elevation in overweight/obese youth. Further studies are required to establish the clinical relevance of HGI for cardiometabolic health in youth.
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참고문헌 (34)
참고문헌 신청
Ng M / 2014 / Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet 384:766~781
Fazeli Farsani S / 2013 / Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents:a systematic review and evaluation of methodological approaches / Diabetologia 56:1471~1488
Nam HK / 2017 / Trends in the prevalence of extreme obesity among Korean children and adolescents from 2001 to 2014. / J Pediatr Endocrinol Metab 30:517~523
이정현 / 2015 / Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam / Annals of Pediatirc Endocrinology & Metabolism 20(4):206~212
Styne DM / 2017 / Pediatric obesity-assessment, treatment, and prevention: an endocrine society clinical practice guideline / J Clin Endocrinol Metab 102:709~757
Fazeli Farsani S / 2013 / Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents:a systematic review and evaluation of methodological approaches / Diabetologia 56:1471~1488
Nam HK / 2017 / Trends in the prevalence of extreme obesity among Korean children and adolescents from 2001 to 2014. / J Pediatr Endocrinol Metab 30:517~523
이정현 / 2015 / Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam / Annals of Pediatirc Endocrinology & Metabolism 20(4):206~212
Styne DM / 2017 / Pediatric obesity-assessment, treatment, and prevention: an endocrine society clinical practice guideline / J Clin Endocrinol Metab 102:709~757
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