지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 377 - 383 (7page)
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초록· 키워드
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Background: Discordances between glycated hemoglobin (HbA1c) levels and glycemic control are common in clinical practice. We aimed to investigate the consistency of the glycation gap with the hemoglobin glycation index (HGI). Methods: From 2016 to 2019, 36 patients with type 2 diabetes were enrolled. HbA1c, glycated albumin (GA), and fasting bloodglucose levels were simultaneously measured and 72-hour continuous glucose monitoring (CGM) was performed on the same day. Repeated tests were performed at baseline and 1 month later, without changing patients’ diabetes management. The HGI was calculated as the difference between the measured HbA1c and the predicted HbA1c that was derived from CGM. The glycation gap wascalculated as the difference between the measured and GA-based predicted HbA1c levels. Results: Strong correlations were found between the mean blood glucose (MBG)-based HGI and the prebreakfast glucose-basedHGI (r=0.867, P<0.001) and between the glycation gap and the MBG-based HGI (r=0.810, P<0.001). A close correlation wasfound between the MBG-based HGI at baseline and that after 1 month (r=0.729, P<0.001), with a y-intercept of 0 and a positiveslope. Conclusion: The HGI and glycation gap were highly reproducible, and the magnitudes of repeated determinations were closely correlated. Patients with similar mean glucose levels may have significantly different HbA1c levels.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Nayak AU / 2019 / Potential clinical error arising from use of HbA1c in diabetes : effects of the glycation gap / Endocr Rev 40:988~999
Khera PK / 2008 / Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation / Diabetes 57:2445~2452
Kim MK / 2017 / Concordance the hemoglobin glycation index with glycation gap using glycated albumin in patients with type 2 diabetes / J Diabetes Complications 31:1127~1131
Hempe JM / 2015 / The hemoglobin glycation index identifies subpopulations with harms or benefits from intensive treatment in the ACCORD trial / Diabetes Care 38:1067~1074
Kim MK / 2018 / Hemoglobin glycation index predicts cardiovascular disease in people with type 2 diabetes mellitus : a 10-year longitudinal cohort study / J Diabetes Complications 32:906~910
Khera PK / 2008 / Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation / Diabetes 57:2445~2452
Kim MK / 2017 / Concordance the hemoglobin glycation index with glycation gap using glycated albumin in patients with type 2 diabetes / J Diabetes Complications 31:1127~1131
Hempe JM / 2015 / The hemoglobin glycation index identifies subpopulations with harms or benefits from intensive treatment in the ACCORD trial / Diabetes Care 38:1067~1074
Kim MK / 2018 / Hemoglobin glycation index predicts cardiovascular disease in people with type 2 diabetes mellitus : a 10-year longitudinal cohort study / J Diabetes Complications 32:906~910
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