지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제18권 제4호
- 발행연도
- 2015.1
- 수록면
- 268 - 275 (8page)
이용수
초록· 키워드
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Purpose: Primary sclerosing cholangitis (PSC) is a rare condition that can be associated with inflammatory bowel disease (IBD). The aim of this study was to evaluate PSC and its association with IBD in children.Methods: We retrospectively enrolled 13 pediatric patients (＜18 years) with PSC treated at Asan Medical Center between June 1989 and December 2013. Clinical findings and long-term outcomes were investigated. During the same period, the incidence of PSC among IBD patients was evaluated among 600 Crohn disease (CD) and 210 ulcerative colitis (UC) patients.Results: All 13 study patients diagnosed with PSC also presented with IBD. Eleven boys and two girls with a median age of 15.0 years old (9.0-17.8 years) were included. The cumulative incidence of PSC for UC was 5.7% (12 of 210) and 0.2% for CD (1 of 600), respectively. PSC occurred during follow-up for IBD for five patients (38.5%) whereas, IBD developed during follow-up for PSC for two patients (15.4%), and was diagnosed during the initial work-up for PSC for 6 patients (46.2%). For the 77.3 month median follow-up period, 9/13 patients (69.2%), neither the clinical symptoms nor blood test results worsened. Two cases (15.4%) developed liver cirrhosis and underwent liver transplantation. Among 13 PSC patients with IBD, two (15.4%) developed colorectal cancer, and no one developed cholangiocarcinoma. Conclusion: All patients with PSC in this study had associated IBD. The incidence of PSC was not rare compared to reports in adults. PSC should be considered during the management of IBD and vice versa in children.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bjornsson E / 2002 / Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis / Gut 51 : 731 ~ 735
Broome U / 1995 / Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential / Hepatology 22 : 1404 ~ 1408
Broome U / 2006 / Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer / Semin Liver Dis 26 : 31 ~ 41
Deneau M / 2013 / Primary sclerosing cholangitis, autoimmune hepatitis, and overlap in Utah children: epidemiology and natural history / Hepatology 58 : 1392 ~ 1400
Farraye FA / 2010 / AGA Institute Medical Position Panel on Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease. AGA medical position statement on
Broome U / 1995 / Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential / Hepatology 22 : 1404 ~ 1408
Broome U / 2006 / Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer / Semin Liver Dis 26 : 31 ~ 41
Deneau M / 2013 / Primary sclerosing cholangitis, autoimmune hepatitis, and overlap in Utah children: epidemiology and natural history / Hepatology 58 : 1392 ~ 1400
Farraye FA / 2010 / AGA Institute Medical Position Panel on Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease. AGA medical position statement on
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