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자료유형
학술저널
저자정보
저널정보
대한한방소아과학회 대한한방소아과학회지 대한한방소아과학회지 제20권 제3호
발행연도
2006.1
수록면
117 - 127 (11page)

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Inhibitory effect of acute pancreatitis by Gagam-daewhangmokdanpi-tang Ahn Jae Sun, Lee Hai Ja, Park Eun Jung Department of Pediatrics, College of Oriental Medicine, Wonkwang Uiversity Objectives : In this study, we investigated the effects of Daehwangmokdanpitang-gagambang(DMG) on treatment for cholecystokinin-octapeptide(CCK)-induced acute pancreatitis(AP) in rats. Methods : Male Wistar rats weighing 200 to 250 g were divided into three groups. The first was normal untreated group, the second was in treatment with DMG group; DMG was administered orally, followed by 75 ㎍/㎏ CCK subcutaneously three times, after 1, 3 and 5 h. This whole procedure was repeated for 5 days. The third was in treatment with saline group, the protocol was the same as in treatment group with DMG. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60, HSP72, ERK, p38 MAPK and the secretion of pro-inflammatory cytokines. Repeated CCK treatment resulted in the typical laboratory and morphological changes of experimentally induced pancreatitis. Results : DMG was significantly decreased the pancreatic weight/body weight ratio in CCK- induced AP and DMG increased HSP60 and HSP72 compared with CCK-induced AP. DMG suppressed ERK and p38 MAPK activation. Additionally, the secretion of IL-1β and TNF-α and the levels of amylase and lipase were lower than that saline. Conclusions : DMG has an effect to treatment for CCK-induced AP.

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