지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 508 - 513 (6page)
이용수
초록· 키워드
오류제보하기
Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1α and downregulated Akt signaling without affecting the stability of HIF-1α protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Cairns RA / 2011 / Regulation of cancer cell metabolism / Nat Rev Cancer 11:85~95
Chang Q / 2011 / Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer / Cancer Res 71:3110~3120
Graeber TG / 1996 / Hypoxiamediated selection of cells with diminished apoptotic potential in solid tumours / Nature 379:88~91
Hill RP / 2009 / Cancer stem cells, hypoxia and metastasis / Semin Radiat Oncol 19:106~111
Kioi M / 2010 / Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice / J Clin Invest 120:694~705
Chang Q / 2011 / Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer / Cancer Res 71:3110~3120
Graeber TG / 1996 / Hypoxiamediated selection of cells with diminished apoptotic potential in solid tumours / Nature 379:88~91
Hill RP / 2009 / Cancer stem cells, hypoxia and metastasis / Semin Radiat Oncol 19:106~111
Kioi M / 2010 / Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice / J Clin Invest 120:694~705
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hypoxia signaling in human diseases and therapeutic targets
Experimental and Molecular Medicine
2019 .01
-
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Experimental and Molecular Medicine
2024 .03
-
Determination of HIF-1α degradation pathways via modulation of the propionyl mark
BMB Reports
2023 .04
-
Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity
Experimental and Molecular Medicine
2015 .01
-
Regulation of HIF-1α stability by lysine methylation
BMB Reports
2016 .01
-
Hypoxia and aging
Experimental and Molecular Medicine
2019 .01
-
Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss
Experimental and Molecular Medicine
2021 .04
-
The Effects of Hypoxia on Liver-specific Functions in Hepatocytes
한국생물공학회 학술대회
2021 .04
-
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
Experimental and Molecular Medicine
2022 .07
-
Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway
조직공학과 재생의학
2021 .12
-
Special issue on hypoxia
Experimental and Molecular Medicine
2019 .01
-
Hypoxia Relieving and Immune Reactivation of the Tumor Microenvironment Using Oxygen Nanosomes
한국생물공학회 학술대회
2023 .10
-
Short-term Hypoxia Exposure Enhances Tumor-killing Activity of Natural Killer Cells
한국생물공학회 학술대회
2024 .09
-
Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
Experimental and Molecular Medicine
2024 .07
-
Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition
Experimental and Molecular Medicine
2019 .01
-
Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism
BMB Reports
2016 .01
-
NDRG3-mediated lactate signaling in hypoxia Kyung Chan
BMB Reports
2015 .01
-
Short Term Hypoxia Pre-treatment Enhances Tumor-killing Activity of Natural Killer Cells in Hypoxic Condition
한국생물공학회 학술대회
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0