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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 151 - 156 (6page)
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초록· 키워드
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The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actinmediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain.
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참고문헌 (50)
참고문헌 신청
Panciera T / 2017 / Mechanobiology of YAP and TAZ in physiology and disease / Nat Rev Mol Cell Biol 18:758~770
Yu FX / 2013 / The Hippo pathway: regulators and regulations / Genes Dev 27:355~371
Piccolo S / 2014 / The biology of YAP/TAZ: hippo signaling and beyond / Physiol Rev 94:1287~1312
Yu FX / 2012 / Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling / Cell 150:780~791
Gaspar P / 2014 / Sensing the local environment: actin architecture and Hippo signalling / Curr Opin Cell Biol 31:74~83
Yu FX / 2013 / The Hippo pathway: regulators and regulations / Genes Dev 27:355~371
Piccolo S / 2014 / The biology of YAP/TAZ: hippo signaling and beyond / Physiol Rev 94:1287~1312
Yu FX / 2012 / Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling / Cell 150:780~791
Gaspar P / 2014 / Sensing the local environment: actin architecture and Hippo signalling / Curr Opin Cell Biol 31:74~83
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