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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 71 - 78 (8page)
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The Hippo signaling pathway plays an essential role in adult-tissue homeostasis and organ-size control. In Drosophila and vertebrates, it consists of a highly conserved kinase cascade, which involves MST and Lats that negatively regulate the activity of the downstream transcription coactivators, YAP and TAZ. By interacting with TEADs and other transcription factors, they mediate both proliferative and antiapoptotic gene expression and thus regulate tissue repair and regeneration. Dysregulation or mutation of the Hippo pathway is linked to tumorigenesis and cancer development. Recent studies have uncovered multiple upstream inputs, including cell density, mechanical stress, G-protein-coupled receptor (GPCR) signaling, and nutrients, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway as effector of these biophysical cues and its potential implications in tissue homeostasis and cancer.
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참고문헌 (95)
참고문헌 신청
Liu CY / 2010 / The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase / J Biol Chem 285:37159~37169
Zhao B / 2008 / TEAD mediates YAPdependent gene induction and growth control / Genes Dev 22:1962~1971
Zhang H / 2009 / TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition / J Biol Chem 284:13355~13362
Zhu C / 2015 / The regulation and function of YAP transcription co-activator / Acta Biochim Biophys Sin (Shanghai) 47:16~28
Zanconato F / 2016 / YAP/TAZ at the roots of cancer / Cancer Cell 29:783~803
Zhao B / 2008 / TEAD mediates YAPdependent gene induction and growth control / Genes Dev 22:1962~1971
Zhang H / 2009 / TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition / J Biol Chem 284:13355~13362
Zhu C / 2015 / The regulation and function of YAP transcription co-activator / Acta Biochim Biophys Sin (Shanghai) 47:16~28
Zanconato F / 2016 / YAP/TAZ at the roots of cancer / Cancer Cell 29:783~803
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논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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The history and regulatory mechanism of the Hippo pathway
BMB Reports
2018 .01
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Regulation and Regulators of the Hippo-YAP/TAZ Pathway
한국생물공학회 학술대회
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Regulation of Hippo signaling by actin remodeling
BMB Reports
2018 .01
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Regulation of the Hippo signaling pathway by ubiquitin modification
BMB Reports
2018 .01
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Upstream paths for Hippo signaling in Drosophila organ development
BMB Reports
2018 .01
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Hippo signaling: Special issue of BMB Reports in 2018
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Clinical implications of the Hippo-YAP pathway in multiple cancer contexts
BMB Reports
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Hippo-YAP/TAZ signaling in angiogenesis
BMB Reports
2018 .01
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Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
BMB Reports
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A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
BMB Reports
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The potential role of YAP in head and neck squamous cell carcinoma
Experimental and Molecular Medicine
2020 .08
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Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
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2017 .01
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DNA binding partners of YAP/TAZ
BMB Reports
2018 .01
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Dishevelling Wnt and Hippo
BMB Reports
2018 .01
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HiPPO 메모리 프레임워크를 사용한 궤적 기반 모방학습
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Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
BMB Reports
2017 .06
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Effect of PFKFB3 on YAP-TEAD Interaction
한국생물공학회 학술대회
2024 .09
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Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation
조직공학과 재생의학
2021 .01
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Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Experimental and Molecular Medicine
2024 .04
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