지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 111 - 115 (5page)
이용수
초록· 키워드
오류제보하기
Caffeine has been proposed to have several beneficial effects on obesity and its related metabolic diseases; however, how caffeine affects adipocyte differentiation has not been elucidated.
In this study, we demonstrated that caffeine suppressed 3T3-L1 adipocyte differentiation and inhibited the expression of CCAAT/enhancer binding protein (C/EBP) and peroxisome proliferator-activated receptor (PPAR), two main adipogenic transcription factors. Anti-adipogenic markers, such as preadipocyte secreted factor (Pref)-1 and Krüppel-like factor 2, remained to be expressed in the presence of caffeine. Furthermore, 3T3-L1 cells failed to undergo typical mitotic clonal expansion in the presence of caffeine. Investigation of hormonal signaling revealed that caffeine inhibited the activation of AKT and glycogen synthase kinase (GSK) 3 in a dose-dependent manner, but not extracellular signal-regulated kinase (ERK).
Our data show that caffeine is an anti-adipogenic bioactive compound involved in the modulation of mitotic clonal expansion during adipocyte differentiation through the AKT/GSK3 pathway.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Friedman JM / 2004 / Modern science versus the stigma of obesity / Nat Med 10:563~569
Kopelman PG / 2000 / Obesity as a medical problem / Nature 404:635~643
Spalding KL / 2008 / Dynamics of fat cell turnover in humans / Nature 453:783~787
Cornelius P / 1994 / Regulation of adipocyte development / Annu Rev Nutr 14:99~129
Lee H / 2009 / Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion / J Biol Chem 284:10601~10609
Kopelman PG / 2000 / Obesity as a medical problem / Nature 404:635~643
Spalding KL / 2008 / Dynamics of fat cell turnover in humans / Nature 453:783~787
Cornelius P / 1994 / Regulation of adipocyte development / Annu Rev Nutr 14:99~129
Lee H / 2009 / Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion / J Biol Chem 284:10601~10609
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
카페인 섭취에 따른 심박수와의 상관관계 분석
Proceedings of KIIT Conference
2020 .10
-
Amyloid-β Impedance Sensor Based on Caffeine for Alzheimer’s Disease
한국고분자학회 학술대회 연구논문 초록집
2019 .04
-
Adipogenic function of tetranectin mediated by enhancing mitotic clonal expansion via ERK signaling
BMB Reports
2021 .01
-
활성탄 입자 크기가 카페인 흡착에 미치는 영향
상하수도학회지
2015 .01
-
Caffeine-induced food-avoidance behavior is mediated by neuroendocrine signals in Caenorhabditis elegans
BMB Reports
2017 .01
-
Nobiletin Induces Brown Adipocyte-like Phenotype and Ameliorates Adipogenic Stress in 3T3L-1 Adipocytes
한국생물공학회 학술대회
2017 .10
-
AGS위암세포에서 AMPK/Akt/GSK-3β 신호경로를 통한 삼채추출물의 항암효과
KSBB Journal
2018 .12
-
유체전단응력을 통한 지방세포의 분화 억제
대한기계학회 춘추학술대회
2015 .11
-
Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3
BMB Reports
2016 .01
-
Effects of Bamboo Stem Extracts on Adipogenic Differentiation
한국생물공학회 학술대회
2017 .10
-
Preparationof chitosan film with caffeine-loaded mesoporous silica for transdermaldelivery
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway
BMB Reports
2021 .01
-
Anti-adipogenic effect of Cudrania tricuspidata Fruit extract in 3T3-L1 adipocytes
한국생물공학회 학술대회
2016 .10
-
Extract from EGM10 Inhibit Insulin-like growth factor Istimulated Metastasis through Suppression of ECM degradation in A549 non-small cell lung cancer cells via Modulation of AKT/GSK-3β Signaling
한국생물공학회 학술대회
2015 .04
-
Hemispheric/Porous Structured Molecularly Imprinted Polymer Films for Caffeine Detection and Their Quartz Crystal Microbalance Analysis
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
Apoptosis effects of extract from Allium hookeri by AMPK/ Akt/ GSK-3β signal pathway in AGS Gastric Cancer Cells
한국생물공학회 학술대회
2018 .04
-
Methyltransferase and demethylase profiling studies during brown adipocyte differentiation
BMB Reports
2016 .01
-
Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation
BMB Reports
2016 .01
-
Theobromine Recruits Brown-like Adipocytes in White Adipocytes and Activates Brown Adipocytes
한국생물공학회 학술대회
2018 .10
-
Extracts from Cnidium monnieri (L.) Cusson Induces Apoptosis and G1 Cell Cycle Arrest through Reducing COX-2 Expression by Regulating the Akt/GSK-3β Signaling Pathways
KSBB Journal
2023 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0