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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 105 - 110 (6page)
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Ursodeoxycholic acid (UDCA), a natural, hydrophilic nontoxic bile acid, is clinically effective for treating cholestatic and chronic liver diseases. We investigated the chronic effects of UDCA on age-related lipid homeostasis and underlying molecular mechanisms. Twenty-week-old C57BL/6 male and female mice were fed a diet with or without 0.3% UDCA supplementation for 25 weeks. UDCA significantly reduced weight gain, adiposity, hepatic triglyceride, and hepatic cholesterol without incidental hepatic injury. UDCA-mediated hepatic triglyceride reduction was associated with downregulated hepatic expression of peroxisome proliferator-activated receptor-, and of other genes involved in lipogenesis (Chrebp, Acaca, Fasn, Scd1, and Me1) and fatty acid uptake (Ldlr, Cd36). The inflammatory cytokines Tnfa, Ccl2, and Il6 were significantly decreased in liver and/or white adipose tissues of UDCA-fed mice. These data suggest that UDCA exerts beneficial effects on age-related metabolic disorders by lowering the hepatic lipid accumulation, while concurrently reducing hepatocyte and adipocyte susceptibility to inflammatory stimuli.
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참고문헌 (27)
참고문헌 신청
Arlia-Ciommo A / 2014 / Mechanisms underlying the anti-aging, anti-tumor effects of lithocholic bile acid / Int J Mol Sci 15:16522~16543
Chiang JY / 2009 / Bile acids: regulation of synthesis / J Lipid Res 50:1955~1966
Amador-Noguez D / 2004 / Gene expression profile of long-lived Ames dwarf mice, Little mice / Aging Cell 3:423~441
Amador-Noguez D / 2007 / Alterations in xenobiotic metabolism in the long-lived Little mice / Aging Cell 6:453~470
Poupon R / 1987 / Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? / Lancet 1:834~836
Chiang JY / 2009 / Bile acids: regulation of synthesis / J Lipid Res 50:1955~1966
Amador-Noguez D / 2004 / Gene expression profile of long-lived Ames dwarf mice, Little mice / Aging Cell 3:423~441
Amador-Noguez D / 2007 / Alterations in xenobiotic metabolism in the long-lived Little mice / Aging Cell 6:453~470
Poupon R / 1987 / Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? / Lancet 1:834~836
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