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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 534 - 534 (1page)
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Ursodeoxycholic acid (UDCA) is a type of bile acid as helps regulate cholesterol homeostasis as well as has antioxidant and anti-inflammatory effects. Furthermore, in our previous study, we discovered that repeated administration of hydrophilic bile acids enhance in vivo bone regeneration in calvarial defect mouse model. However, repeated injections of bile acid cause various side effects. Nanoparticles are used because they sustained release and increase drug stability. For these reasons, we designed a polymeric prodrug of UDCA nanoparticles (PUDCA) using peroxalate ester linkages to induce the long-term release of UDCA and scavenge hydrogen peroxide. In this study, we analyze effect of PUDCA in adipo-, osteogenic differentiat ... 전체 초록 보기
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