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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 713 - 723 (11page)
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Cell-based bone regeneration is generally pursued based on single cell type approaches, for which human adipose tissue-derived mesenchymal stromal cells (AT-MSCs) are frequently used, owing to their easy accessibility and relatively large yield. In view of multiple cell types involved in physiological bone regeneration, this study aimed to evaluate the osteogenic differentiation of AT-MSCs upon co-culture with endothelial cells or macrophages in a direct or indirect in vitro co-culture set-up. Our hypotheses were that 1) endothelial cells and macrophages stimulate AT-MSCs proliferation and osteogenic differentiation and that 2) these two cell types will more profoundly affect osteogenic differentiation of AT-MSCs in a direct compared to an indirect co-culture set-up, because of the possibility for both cell-cell interactions and effects of secreted soluble factors in the former. Osteogenic differentiation of AT-MSCs was stimulated by endothelial cells, particularly in direct co-cultures. Although initial numbers of AT-MSCs in co-culture with endothelial cells were 50% compared to monoculture controls, equal levels of mineralization were achieved. Macrophages showed a variable effect on AT-MSCs behavior for indirect co-cultures and a negative effect on osteogenic differentiation of AT-MSCs in direct co-cultures, the latter likely due to species differences of the cell types used. The results of this study demonstrate potential for cell combination strategies in bone regenerative therapies.
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참고문헌 (37)
참고문헌 신청
Laurie SW / 1984 / Donor-site morbidity after harvesting rib and iliac bone / Plast Reconstr Surg 73:933~938
Kimelman N / 2007 / Review: gene- and stem cell-based therapeutics for bone regeneration and repair / Tissue Eng 13:1135~1150
Helder MN / 2007 / Stem cells from adipose tissue allow challenging new concepts for regenerative medicine / Tissue Eng 13:1799~1808
Janicki P / 2011 / Prediction of in vivo bone forming potency of bone marrow-derived human mesenchymal stem cells / Eur Cell Mater 21:488~507
Stolzing A / 2008 / Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies / Mech Ageing Dev 129:163~167
Kimelman N / 2007 / Review: gene- and stem cell-based therapeutics for bone regeneration and repair / Tissue Eng 13:1135~1150
Helder MN / 2007 / Stem cells from adipose tissue allow challenging new concepts for regenerative medicine / Tissue Eng 13:1799~1808
Janicki P / 2011 / Prediction of in vivo bone forming potency of bone marrow-derived human mesenchymal stem cells / Eur Cell Mater 21:488~507
Stolzing A / 2008 / Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies / Mech Ageing Dev 129:163~167
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