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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 259 - 267 (9page)
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Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types. The potential of MSCs for differentiation and proliferation depends on the control of various processes. In this study, we have investigated the effects of low temperature on the Schwann-like cell differentiation of human bone marrow mesenchymal stem cells (BM-MSCs). The growth of BM-MSCs decreased at low temperature, but increased Schwann-like cell differentiation. The expression of cell surface antigen decreased CD73, CD105, and CD90, which are known markers of MSCs at 35°C. Also, the levels of matrix RNA [S100, glial fibrillary acidic protein (GFAP), p75, myelin basic protein, P0, and others] at 35°C in the differentiation culture were higher than those at 37°C in the differentiation culture, and S100, p75, and GFAP proteins were expressed more than at 37°C. GFAP and S100 were stained strongly at 35°C by immunohistochemical examination. These data demonstrate that culturing BM-MSCs at reduced temperature can improve differentiation into Schwann-like cells.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Sulaiman OA / 2000 / Effects of short- and long-term Schwann cell denervation on peripheral nerve regeneration, myelination, and size / Glia 32:234~246
Morrissey TK / 1991 / Isolation and functional characterization of Schwann cells derived from adult peripheral nerve / J Neurosci 11:2433~2442
An YH / 2003 / Effect of rat Schwann cell secretion on proliferation and differentiation of human neural stem cells / Biomed Environ Sci 16:90~94
Kingham PJ / 2007 / Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro / Exp Neurol 207:267~274
Tohill M / 2004 / Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration / Neurosci Lett 362:200~203
Morrissey TK / 1991 / Isolation and functional characterization of Schwann cells derived from adult peripheral nerve / J Neurosci 11:2433~2442
An YH / 2003 / Effect of rat Schwann cell secretion on proliferation and differentiation of human neural stem cells / Biomed Environ Sci 16:90~94
Kingham PJ / 2007 / Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro / Exp Neurol 207:267~274
Tohill M / 2004 / Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration / Neurosci Lett 362:200~203
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