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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 683 - 693 (11page)
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초록· 키워드
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BACKGROUND: Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited. METHODS: Bone marrow-derived MSCs (BM-MSCs) were generated that overexpressed the erythropoietin (EPO) gene using a lentivirus. Cell Counting Kit-8 was used to detect the viability of BM-MSCs after overexpressing EPO. Cell migration and apoptosis were verified using Boyden chamber and flow cytometry, respectively. Finally, the anti-fibrosis efficacy of EPO-MSCs was evaluated in vivo using immunohistochemical analysis. RESULTS: EPO overexpression promoted cell viability and migration of BM-MSCs without inducing apoptosis, and EPO-MSC treatment significantly alleviated liver fibrosis in a carbon tetrachloride (CCl4) induced mouse liver fibrosis model. CONCLUSION: EPO-MSCs enhance anti-fibrotic efficacy, with higher cell viability and stronger migration ability compared with treatment with BM-MSCs only. These findings support improving the efficiency of MSCs transplantation as a potential therapeutic strategy for liver fibrosis.
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참고문헌 (33)
참고문헌 신청
Elpek GO / 2014 / Cellular and molecular mechanisms in the pathogenesis of liver fibrosis : an update / World J Gastroenterol 20:7260~7276
Khatun M / 2019 / Mechanisms underlying hepatitis C virusassociated hepatic fibrosis / Cells 8:1249
Karsdal MA / 2020 / Collagen biology and non-invasive biomarkers of liver fibrosis / Liver Int 40:736~750
Dolin CE / 2020 / The matrisome, inflammation, and liver disease / Semin Liver Dis 40:180~188
Naji A / 2019 / Biological functions of mesenchymal stem cells and clinical implications / Cell Mol Life Sci 76:3323~3348
Khatun M / 2019 / Mechanisms underlying hepatitis C virusassociated hepatic fibrosis / Cells 8:1249
Karsdal MA / 2020 / Collagen biology and non-invasive biomarkers of liver fibrosis / Liver Int 40:736~750
Dolin CE / 2020 / The matrisome, inflammation, and liver disease / Semin Liver Dis 40:180~188
Naji A / 2019 / Biological functions of mesenchymal stem cells and clinical implications / Cell Mol Life Sci 76:3323~3348
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