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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 689 - 694 (6page)
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Ethical and safety issues have rendered mesenchymal stem cells (MSCs) popular candidates in regenerative medicine, but their therapeutic capacity is lower than that of induced pluripotent stem cells (iPSCs). This study compared original, dental tissue-derived MSCs with re-differentiated MSCs from iPSCs (iPS-MSCs). CD marker expression in iPS-MSCs was similar to original MSCs. iPS-MSCs expressed higher in pluripotent genes, but lower levels in mesodermal genes than MSCs. In addition, iPS-MSCs did not form teratomas. All iPSCs carried mtDNA mutations; some shared with original MSCs and others not previously detected therein. Shared mutations were synonymous, while novel mutations were non-synonymous or located on RNA-encoding genes. iPS-MSCs also harbored mtDNA mutations transmitted from iPSCs. Selected iPS-MSCs displayed lower mitochondrial respiration than original MSCs. In conclusion, screening for mtDNA mutations in iPSC lines for iPS-MSCs can identify mutation-free cell lines for therapeutic applications.
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참고문헌 (32)
참고문헌 신청
Alan Trounson CM / 2015 / Stem cell therapies in clinical trials : progress and challenges / Cell Stem Cell 17:11~22
Ghislain Moussavou / 2013 / Role of gangliosides in the differentiation of human mesenchymal-derived stem cells into osteoblasts and neuronal cells / BMB Reports 46(11):527~532
Zhao Q / 2015 / MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs / Proc Natl Acad Sci U S A 112:530~535
김창성 / 2015 / iPSC technology-Powerful hand for disease modeling and therapeutic screen / BMB Reports 48(5):256~265
Zhao C / 2018 / Generation and applications of induced pluripotent stem cell-derived mesenchymal stem cells / Stem Cells Int 2018:9601623
Ghislain Moussavou / 2013 / Role of gangliosides in the differentiation of human mesenchymal-derived stem cells into osteoblasts and neuronal cells / BMB Reports 46(11):527~532
Zhao Q / 2015 / MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs / Proc Natl Acad Sci U S A 112:530~535
김창성 / 2015 / iPSC technology-Powerful hand for disease modeling and therapeutic screen / BMB Reports 48(5):256~265
Zhao C / 2018 / Generation and applications of induced pluripotent stem cell-derived mesenchymal stem cells / Stem Cells Int 2018:9601623
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