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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 437 - 444 (8page)
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Different types of eukaryotic cells may adopt seemingly distinct modes of directional cell migration. However, several core aspects are regarded common whether the movement is either ameoboidal or mesenchymal. The region of cells facing the attractive signal is often termed leading edge where lamellipodial structures dominates and the other end of the cell called rear end is often mediating cytoskeletal F-actin contraction involving Myosin-II. Dynamic remodeling of cell-to-matrix adhesion involving integrin is also evident in many types of migrating cells. All these three aspects of cell migration are significantly affected by signaling networks of TorC2, TorC1, and PP2A/B56. Here we review the current views of the mechanistic understanding of these regulatory signaling networks and how these networks affect eukaryotic cell migration.
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참고문헌 (25)
참고문헌 신청
Ahn JH / 2007 / Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit / Proc Natl Acad Sci U S A 104 : 2979 ~ 2984
Bryant JC / 1999 / Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit / Biochem J 339 : 241 ~ 246
Di Como CJ / 1996 / Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases / Genes Dev 10 : 1904 ~ 1916
Eichhorn PJA / 2009 / Protein phosphatase 2A regulatory subunits and cancer / Biochimica et Biophysica Acta 1795 : 1 ~ 15
Funamoto S / 2002 / Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis / Cell 109 : 611 ~ 623
Bryant JC / 1999 / Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit / Biochem J 339 : 241 ~ 246
Di Como CJ / 1996 / Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases / Genes Dev 10 : 1904 ~ 1916
Eichhorn PJA / 2009 / Protein phosphatase 2A regulatory subunits and cancer / Biochimica et Biophysica Acta 1795 : 1 ~ 15
Funamoto S / 2002 / Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis / Cell 109 : 611 ~ 623
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