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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 214 - 219 (6page)
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Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Achkar NP / 2016 / miRNA Biogenesis: A Dynamic Pathway / Trends Plant Sci 21 : 1034 ~ 1044
Bereiter-Hahn J / 2010 / Mitochondrial dynamics / Int Rev Cell Mol Biol 284 : 1 ~ 65
Catalanotto C / 2016 / MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions / Int J Mol Sci 17 : 1712 ~
Chang CR / 2010 / Dynamic regulation of mitochondrial fission through modification of the dynaminrelated protein Drp1 / Ann NY Acad Sci 1201 : 34 ~ 39
Detmer SA / 2007 / Functions and dysfunctions of mitochondrial dynamics / Nat Rev Mol Cell Bio 8 : 870 ~ 879
Bereiter-Hahn J / 2010 / Mitochondrial dynamics / Int Rev Cell Mol Biol 284 : 1 ~ 65
Catalanotto C / 2016 / MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions / Int J Mol Sci 17 : 1712 ~
Chang CR / 2010 / Dynamic regulation of mitochondrial fission through modification of the dynaminrelated protein Drp1 / Ann NY Acad Sci 1201 : 34 ~ 39
Detmer SA / 2007 / Functions and dysfunctions of mitochondrial dynamics / Nat Rev Mol Cell Bio 8 : 870 ~ 879
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