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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
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참고문헌 (26)
참고문헌 신청
Anderson S / 1981 / Sequence and organization of the human mitochondrial genome / Nature 290 : 457 ~ 465
Biswas G / 2003 / Mitochondria to nucleus stress signaling : a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta / J
Brand MD / 2010 / The sites and topology of mitochondrial superoxide production / Exp Gerontol 45 : 466 ~ 472
Calkins MJ / 2011 / Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer’s disease mice : implications for impaired mitoch
Circu ML / 2010 / Reactive oxygen species, cellular redox systems, and apoptosis / Free Radic Biol Med 48 : 749 ~ 762
Biswas G / 2003 / Mitochondria to nucleus stress signaling : a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta / J
Brand MD / 2010 / The sites and topology of mitochondrial superoxide production / Exp Gerontol 45 : 466 ~ 472
Calkins MJ / 2011 / Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer’s disease mice : implications for impaired mitoch
Circu ML / 2010 / Reactive oxygen species, cellular redox systems, and apoptosis / Free Radic Biol Med 48 : 749 ~ 762
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