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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 467 - 472 (6page)
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Heat shock increases skin temperature during sun exposure and some evidence indicates that it may be involved in skin aging. The antioxidant response mediated by the transcription factor NF-E2-related factor 2 (Nrf2) is a critically important cellular defense mechanism that serves to limit skin aging. We investigated the effects of heat shock on collagenase expression when the antioxidant defense system was downregulated by knockdown of Nrf2. GSH and collagenases were analyzed, and the expression of inducible Nrf2, HO-1, and NQO1 was measured. HS68 cells were transfected with small interfering RNA against Nrf2. Heat shock induced the downregulation of Nrf2 in both the cytosol and nucleus and reduced the expression of HO-1, GSH, and NQO1. In addition, heat-exposed Nrf2-knockdown cells showed significantly increased levels of collagenase protein and decreased levels of procollagen. Our data suggest that Nrf2 plays an important role in protection against heat shock-induced collagen breakdown in skin.
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참고문헌 (26)
참고문헌 신청
Chen X-L / 2004 / Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases / Curr Pharm Des 10:879~891
van der Rest M / 1991 / Collagen family of proteins / FASEB J 5:2814~2823
Chung JH / 2001 / Modulation of skin collagen metabolism in aged and photoaged human skin in vivo / J Invest Dermatol 117:1218~1224
윤병학 / 2013 / Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) / BMB Reports 46(9):465~470
이은경 / 2013 / Low-dose radiation activates Nrf1/2 through reactive species and the Ca2+/ERK1/2 signaling pathway in human skin fibroblast cells / BMB Reports 46(5):258~263
van der Rest M / 1991 / Collagen family of proteins / FASEB J 5:2814~2823
Chung JH / 2001 / Modulation of skin collagen metabolism in aged and photoaged human skin in vivo / J Invest Dermatol 117:1218~1224
윤병학 / 2013 / Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) / BMB Reports 46(9):465~470
이은경 / 2013 / Low-dose radiation activates Nrf1/2 through reactive species and the Ca2+/ERK1/2 signaling pathway in human skin fibroblast cells / BMB Reports 46(5):258~263
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