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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 636 - 641 (6page)
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There are controversial findings regarding the roles of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway on bone metabolism under oxidative stress.
We investigated how Nrf2/HO-1 pathway affects osteoblast differentiation of MC3T3-E1 cells in response to hydrogen peroxide (H2O2), N-acetyl cysteine (NAC), or both. Exposing the cells to H2O2 decreased the alkaline phosphatase activity, calcium accumulation, and expression of osteoblast markers, such as osteocalcin and runt-related transcription factor-2. In contrast, H2O2 treatment increased the expression of Nrf2 and HO-1 in the cells. Treatment with hemin, a chemical HO-1 inducer, mimicked the inhibitory effect of H2O2 on osteoblast differentiation by increasing the HO-1 expression and decreasing the osteogenic marker genes. Pretreatment with NAC restored all changes induced by H2O2 to near normal levels in the cells. Collectively, our findings suggest that H2O2-mediated activation of Nrf2/HO-1 pathway negatively regulates the osteoblast differentiation, which is inhibited by NAC.
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참고문헌 (25)
참고문헌 신청
Ahanger AA / 2010 / Pro-healing potential of hemin: an inducer of heme oxygenase-1 / Eur J Pharmacol 645 : 165 ~ 170
Arai M / 2007 / Effects of reactive oxygen species(ROS)on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells / IUBMB Life 59 : 27 ~ 33
Bai XC / 2004 / Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB / Biochem Biophys Res Commun 314 : 197 ~ 207
Banfi G / 2008 / Oxidative stress, free radicals and bone remodeling / Clin Chem Lab Med 46 : 1550 ~ 1555
Chen JS / 2011 / Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkg
Arai M / 2007 / Effects of reactive oxygen species(ROS)on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells / IUBMB Life 59 : 27 ~ 33
Bai XC / 2004 / Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB / Biochem Biophys Res Commun 314 : 197 ~ 207
Banfi G / 2008 / Oxidative stress, free radicals and bone remodeling / Clin Chem Lab Med 46 : 1550 ~ 1555
Chen JS / 2011 / Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkg
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