지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 473 - 478 (6page)
이용수
초록· 키워드
오류제보하기
The NEK6 (NIMA-related kinases 6) is reported to play po-tential roles in tumorigenesis. Although it is suggested to function in several cellular pathways, the underlying mechanism in tumorigenesis is still largely unknown. In the present study, we discovered interaction of NEK6 with Smad4, a key member of transforming growth factor beta (TGFβ) pathway. Over-expression of NEK6 in hepatocellular carcinoma (HCC) cell lines suppresses TGFβ- mediated transcription activity in a kinase activity-dependent manner. In addition, NEK6 suppresses the cell growth arrest induced by TGFβ. Mechanically, NEK6 blocks nuclear translocation of Smad4, which is essential for TGF βfunction. Moreover, we identified that NEK6 could be regulated by TGFβand hypoxia. Our study sheds new light on the roles of NEK6 in canonical TGFβ/Smad pathway and tum-origenesis.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Barrios-Rodiles M / 2005 / High-throughput mapping of a dynamic signaling network in mammalian cells / Science 307 : 1621 ~ 1625
Belham C / 2003 / A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases / J Biol Chem 278 : 34897 ~ 34909
Cao X / 2012 / Clinical and biological significance of never in mitosis gene A-related kinase 6(NEK6)expression in hepatic cell cancer / Pathol Oncol Res 18 : 201 ~ 207
Chen J / 2006 / Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients / Biochem Biophys Res Commun
Dennler S / 1998 / Direct binding of Smad3 and Smad4to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene / EMBO J 17
Belham C / 2003 / A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases / J Biol Chem 278 : 34897 ~ 34909
Cao X / 2012 / Clinical and biological significance of never in mitosis gene A-related kinase 6(NEK6)expression in hepatic cell cancer / Pathol Oncol Res 18 : 201 ~ 207
Chen J / 2006 / Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients / Biochem Biophys Res Commun
Dennler S / 1998 / Direct binding of Smad3 and Smad4to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene / EMBO J 17
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Nek5000 기반의 마이크로버블 난류 유동 불확실도 정량화 평가
한국전산유체공학회 학술대회논문집
2023 .05
-
Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail
BMB Reports
2017 .01
-
TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model
Experimental and Molecular Medicine
2017 .01
-
A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells
Experimental and Molecular Medicine
2021 .05
-
Eupatilin Inhibits Hepatic Fibrosis by Blocking TGF-β1 /non-Smad Signaling
한국생물공학회 학술대회
2018 .04
-
TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13
조직공학과 재생의학
2021 .10
-
Controlling flow around a circular cylinder using dual synthetic jets via deep reinforcement learning
한국가시화정보학회 학술발표대회 논문집
2023 .11
-
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β
Experimental and Molecular Medicine
2021 .09
-
Improvement of Human Transforming Growth Factor-β1 Expression in Chinese Hamster Ovary Cells by Post-transcriptional Regulation Element
한국생물공학회 학술대회
2021 .10
-
Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-β/collagen athway in preeclampsia
Experimental and Molecular Medicine
2019 .01
-
Exosomes Derived from Human Adipose Mesenchymal Stem Cells Inhibits Fibrosis and Treats Oral Submucous Fibrosis via the miR-181a-5p/Smad2 Axis
조직공학과 재생의학
2024 .01
-
Transforming growth factor β1 enhances adhesion of endometrial cells to mesothelium by regulating integrin expression
BMB Reports
2017 .01
-
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
Experimental and Molecular Medicine
2020 .01
-
Lin28a attenuates TGF-β-induced renal fibrosis
BMB Reports
2020 .01
-
Osteopontin contributes to late-onset asthma phenotypes in adult asthma patients
Experimental and Molecular Medicine
2020 .02
-
Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability
Experimental and Molecular Medicine
2016 .01
-
Regulation of alternative macrophage activation by MSCs derived hypoxic conditioned medium, via the TGF-β1/Smad3 pathway
BMB Reports
2020 .01
-
Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-β1 pathway
Experimental and Molecular Medicine
2019 .01
-
Development of Cell/microparticle Spheroid System to Optimize TGF-b1 Concentration in Chondrogenic Differentiation
한국고분자학회 학술대회 연구논문 초록집
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0