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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 73 - 78 (6page)
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Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis and lymphangiogenesis in vertebrates. Each of the VEGF has specific receptors, which it activates by binding to the extracellular domain of the receptors, and, thus, regulates the angiogenic balance in the early embryonic and adult stages. However, de-regulation of the VEGF-VEGFR implicates directly in various diseases, particularly cancer. Moreover, tumor growth needs a dedicated blood supply to provide oxygen and other essential nutrients. Tumor metastasis requires blood vessels to carry tumors to distant sites, where they can implant and begin the growth of secondary tumors. Thus, investigation of signaling systems related to the human disease, such as VEGF-VEGFR, will facilitate the development of treatments for such illnesses.
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참고문헌 (62)
참고문헌 신청
Birbrair A / 2015 / Pericytes at the intersection between tissue regeneration and pathology / Clin Sci (Lond) 128:81~93
Birbrair A / 2014 / Type-2 pericytes participate in normal and tumoral angiogenesis / Am J Physiol Cell Physiol 307:C25~C38
Alitalo K / 2002 / Molecular mechanisms of lymphangiogenesis in health and disease / Cancer Cell 1:219~227
Davis S / 1996 / Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning / Cell 87:1161~1169
Ferrara N / 1997 / The biology of vascular endothelial growth factor / Endocr Rev 18:4~25
Birbrair A / 2014 / Type-2 pericytes participate in normal and tumoral angiogenesis / Am J Physiol Cell Physiol 307:C25~C38
Alitalo K / 2002 / Molecular mechanisms of lymphangiogenesis in health and disease / Cancer Cell 1:219~227
Davis S / 1996 / Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning / Cell 87:1161~1169
Ferrara N / 1997 / The biology of vascular endothelial growth factor / Endocr Rev 18:4~25
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