지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 174 - 181 (8page)
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초록· 키워드
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IPS-05002, a novel antagonist of integrin α5β1, was screened from a phytochemical compound library using ProteoChip-based integrin α5β1-fibronectin interaction assay method. The novel compound inhibited VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration in a dose-dependent manner. It also suppressed tubular network formation. Differential expression profiling of cell cycle proteins in VEGF-induced HUVECs in the presence of IPS-05002 showed up-regulation of IKB-β, XRCC4, and down-regulation of Cdc6 compared with HUVECs induced by VEGF alone. In conclusion, these data suggest that IPS-05002 will be a potent inhibitor for VEGF-mediated angiogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Folkman, J. / 1991 / Angiogenesis / J. Biol. Chem 267:10931~10934
Folkman, J. / 2003 / Angiogenesis and apoptosis / Semin. Cancer Biol 13:159~167
Fan, T. P. / 1995 / Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy / Trends Pharmacol. Sci 16:57~66
Naumov, G. N. / 2006 / Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switc / Cell Cycle 5:1779~1787
Nguyen, M. / 1997 / Angiogenic factors as tumor markers / Invest New Drugs 15:29~37
Folkman, J. / 2003 / Angiogenesis and apoptosis / Semin. Cancer Biol 13:159~167
Fan, T. P. / 1995 / Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy / Trends Pharmacol. Sci 16:57~66
Naumov, G. N. / 2006 / Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switc / Cell Cycle 5:1779~1787
Nguyen, M. / 1997 / Angiogenic factors as tumor markers / Invest New Drugs 15:29~37
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